Impact of long-term doxycycline on lung function & exacerbations: A real-world open, prospective pilot observation on chronic obstructive pulmonary disease.

Background & Objectives: Upregulation of matrix metalloproteinases (MMPs) is related to the pathogenesis of chronic obstructive pulmonary disease (COPD). We aimed at assessing the tolerability and impact of long-term use of MMP inhibitor doxycycline in COPD.

Methods: A cohort of COPD patients was randomized to continue a uniform COPD treatment with or without add-on long-term oral doxycycline.

A novel approach towards non-obstructive detection and classification of COPD using ECG derived respiration.

The alarming rate of mortality and disability due to Chronic Obstructive Pulmonary Disease (COPD) has become a serious health concern worldwide. The progressive nature of this disease makes it inevitable to detect this disease in its early stages, leads to a greater demand for developing non-obstructive and reliable technology for COPD detection. The use of highly patient-effort dependent, time-consuming, and expensive methods are some major inherent limitations of previous techniques.

Effect of doxycyline in chronic obstructive pulmonary disease - An exploratory study.

Purpose: Various mechanisms, including oxidative stress, inflammation, and protease-antiprotease imbalance are proposed for the progressive decline in lung function in chronic obstructive pulmonary disease (COPD). Doxycycline, a broad spectrum tetracycline antibiotic, is reported to have non-antimicrobial matrix metalloproteinases (MMP) inhibitory action in various inflammatory conditions. The effect of doxycycline in COPD is hereby assessed in the present randomized prospective study.