Publications by authors named "Sureshkumar Mulampurath Achuthan Pillai"
Article Synopsis
- Endometrial cancer (EC) shows abnormal activation of the PI3K/Akt/mTOR signaling pathway, and while mTOR inhibitors have been used in treatment, their effectiveness has been limited.
- Researchers found that inhibiting KDM1A, an epigenetic modifier overexpressed in EC, enhances the effects of mTOR inhibitors, significantly reducing cell viability and migration in cancer cells.
- Studies indicate that KDM1A inhibition reduces activation of the mTOR pathway and related survival signals, suggesting that a combination therapy using both KDM1A and mTOR inhibitors could improve outcomes for EC patients.
