Publications by authors named "Suresh Velayutham"
Article Synopsis
- Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting synovial joints, often linked to environmental factors and genetics, characterized by both joint and extra-articular symptoms.
- The review explores the therapeutic potential of natural products in managing arthritis through three methodologies: in-silico analysis identifies molecular targets, in-vivo studies assess safety and effectiveness in reducing inflammation, and in-vitro studies examine cellular interactions and signaling pathways.
- Overall, the study suggests that natural compounds could serve as valuable adjuncts to traditional RA treatments, highlighting their anti-inflammatory properties and the need for further research to enhance their therapeutic benefits.
Exploring Computational Advancements in ADME: Essential Insights for Drug Disposition.
Zhongguo Ying Yong Sheng Li Xue Za Zhi
November 2024
The physicochemical properties of the physiological makeup and the chemical componentof the system make this challenging throughout strenuous procedure. The current review concentrated on in silico modelling of drug disposition, involving absorption process, distribution process, and excretion process and includes thorough knowledge of various database expeditions, the development of a pharmacophore model, molecular docking studies, homology modelling supported sequence similarity and quantitative structure-activity relationships (QSAR)/ quantitative structure-property relationships (QSPR) evaluation along with all information about drug movement and related computational tools for understanding potential chemical and pathophysiological changes. The primary development in ADMET modeling in current times has been the clarification of the function and effective modeling of various transporters.
View Article and Find Full Text PDFObjective: To evaluate the antiulcer activity of Samanea saman (Jacq) Merr bark on ethanol and stress induced gastric lesions in albino rats.
Materials And Methods: Gastric lesions were induced in rats by oral administration of absolute ethanol (5 ml/kg) and stress induced by water immersion. The antiulcer activity of methanolic extract of Samanea saman (Jacq) Merr bark (100 mg/kg, 200 mg/kg, 400 mg/kg) was compared with standard drugs.