Kruskal Szekeres generative adversarial network augmented deep autoencoder for colorectal cancer detection.

Cancer involves abnormal cell growth, with types like intestinal and oesophageal cancer often diagnosed in advanced stages, making them hard to cure. Symptoms are like burning sensations in the stomach and swallowing difficulties are specified as colorectal cancer. Deep learning significantly impacts the medical image processing and diagnosis, offering potential improvements in accuracy and efficiency.

A brief study on the role of cerium oxide nanoparticles in growth and alleviation of mercury-induced stress in Vigna radiata and soil bacteria Bacillus coagulans.

Cerium oxide nanoparticles have so far been investigated for their role as an antioxidant in pathologies involving inflammation and high oxidative stress. However, its role as a plant and bacterial growth modulator and heavy metal stress reliever has been overlooked to date. Heavy metal contamination poses a major threat to mankind and the life-sustaining ecosystem.

Biostial iatrogenic coronary artery stenosis: a rare complication of aortic valve surgery successfully treated with percutaneous coronary stenting.

A 66-year-old woman presented 4 months after conventional surgical aortic valve replacement with an acute coronary syndrome resulting from rare iatrogenic biostial left main and right coronary artery stenoses, which were successfully treated with percutaneous coronary stenting, optimized by intracoronary imaging.

Balloon aortic valvuloplasty in contemporary practice.

Background: There has been a revival of balloon aortic valvuloplasty (BAV) for severe aortic stenosis, as a result of an increasing number of patients undergoing trans-catheter aortic valve implantation (TAVI). However, there has not been universal adoption of BAV as a standalone, nor bridging therapy.

Methods: A retrospective analysis of the practice at our institution between June 2009 and May 2016 was performed.

Predictive value of atrial high-rate episodes for arterial stiffness and endothelial dysfunction in dual-chamber pacemaker patients.

Background: Various pacing studies have demonstrated an association between right ventricular pacing (RVp) and atrial fibrillation (AF), even after preserving atrioventricular (AV) synchrony. We aimed to assess the interaction between arterial stiffness, endothelial function and atrial high-rate episodes (AHRE) in patients with dual-chamber pacemakers.

Methods: We studied 101 patients with dual-chamber pacemakers incorporated with sophisticated AF detection and therapy algorithms.

Prognostic role of plasma von Willebrand factor and soluble E-selectin levels for future cardiovascular events in a 'real-world' community cohort of patients with atrial fibrillation.

Background: Endothelial damage/dysfunction may contribute to a prothrombotic state in patients with atrial fibrillation (AF) and the increased risk of thromboembolism and cardiovascular events. Raised plasma von Willebrand factor (vWf), an established marker of endothelial damage/dysfunction, has been associated with stroke and vascular events, at least in a clinical trial population. Soluble E-selectin (sE-sel) is another biomarker of endothelial activation/dysfunction, with more limited data on prognostic outcomes in AF.

Atrial fibrillation, arrhythmia burden and thrombogenesis.

Atrial fibrillation (AF) is the most common cardiac arrhythmia, which is associated with substantial risk of stroke and thromboembolism. The epidemiology and health care burden associated with AF have increased significantly, and will continue to rise. Until recently, the concept and/or quantification of disease burden in AF tended to be ignored nor its consequences recognised.

Assessment of left atrial volume: a focus on echocardiographic methods and clinical implications.

Left atrial enlargement is an important predictor of cardiovascular events such as atrial fibrillation, stroke, heart failure and mortality. A number of methods of left atrial size assessment by echocardiography have been reported, from the simple antero-posterior diameter in the parasternal long axis view to the more complex ellipsoid, area-length and Simpson's method of estimating left atrial volume. These different methods of left atrial size assessment, their clinical implications and some common pitfalls are discussed in this review.

Safety and cost-effectiveness of same day permanent pacemaker implantation.

An overnight stay after permanent pacemaker implantation has major cost implications for healthcare systems. Same day pacing could be effective in alleviating this. We evaluated our elective same day pacing practice to determine safety and cost-effectiveness.

Assessment of endothelial dysfunction.

The pathophysiology underlying the initiation and progression of cardiovascular disorders is highly complex and multifactorial. The endothelium also plays a crucial role in the pathogenesis of thrombogenesis and atherogenesis, and a continuum of endothelial activation, dysfunction or damage is evident in many cardiovascular disorders both at the macro and microscopic level(s). This review article aims to provide an overview of the assessment of endothelial (dys)function and discuss the implications and limitations of such assessments.

Unusual presentation of thyrotoxicosis as complete heart block and renal failure: a case report.

Introduction: Thyrotoxicosis is a clinical entity often very difficult to diagnose without biochemical confirmation as its clinical features can be highly varied. The most common cardiac manifestations of thyrotoxicosis are resting sinus tachycardia, supraventricular tachycardia including atrial fibrillation and atrial flutter with or without cardiac failure. Bradycardia and atrio-ventricular conduction defects are very uncommon in thyrotoxicosis.

Assessment of endothelial (dys)function in atrial fibrillation.

Atrial fibrillation (AF) is associated with an increased risk of mortality and morbidity from stroke and thromboembolism. Endothelial damage or dysfunction may contribute to this increased risk of thromboembolism via the mediation of a prothrombotic or hypercoagulable state. However, the precise pathophysiological mechanism(s) relating endothelial (dys)function to AF and thromboembolism are yet to be fully elucidated.

Alcohol and illicit drug use as precipitants of atrial fibrillation in young adults: a case series and literature review.

Background: Atrial fibrillation in young patients ( View Article and Find Full Text PDF

Novel antiarrhythmic drugs in atrial fibrillation: focus on tedisamil.

Background: Even established and effective antiarrhythmic drugs (AADs) in atrial fibrillation (AF) are limited by their pro-arrhythmic and non-target organ side effects. Therefore the search continues for safer and effective new AADs.

Objective: This review will examine a novel AAD, tedisamil--a multichannel potassium channel blocker--and its antiarrhythmic properties, focusing on AF.

Antiarrhythmic drugs for atrial fibrillation: focus on dronedarone.

Patients with atrial fibrillation have an increased risk of stroke and heart failure, as well as impairment of their quality of life. Most trials have primarily focused on the prevention of stroke and heart failure, and the improvement of symptoms in these patients. More recently, a rate-control strategy has been reported to be a noninferior strategy compared with a rhythm-control strategy in atrial fibrillation patients.

Asymptomatic hypoxia in a young pregnant lady--unusual presentation of atrial septal defect.

Atrial septal defect (ASD) accounts for approximately a third of all congenital heart disease in adults. It is rarely diagnosed and less likely to cause any symptoms during infancy, but approximately more than half become symptomatic around their fifth decade. In clinical setting it commonly presents as exertional dyspnoea, atrial arrhythmias, right heart failure and is rarely related to the thromboembolic complications due to paradoxical embolism.

Temporary pacing wire in the coronary sinus: a novel treatment of acute heart failure?

Treatment of acute heart failure relies initially on medical therapy. Patients can be considered for cardiac resynchronization therapy once they are able to lie flat for several hours. However, placement of a temporary pacing wire (TPW) into the coronary sinus may allow the patient to receive resynchronization therapy in the acute phase.

Acute ST-elevation myocardial infarction secondary to paradoxical embolism.

Acute ST-elevation myocardial infarction (STEMI) is a life threatening condition usually caused by rupture of an atheromatous plaque in the coronary arteries. Other causes, such as septic emboli, cholesterol emboli and cocaine abuse have been reported. We report a case of acute STEMI in a young female without any vascular risk factors due to a presumptive paradoxical embolism via a secundum atrial septal defect (ASD).