This study evaluates a family with two siblings having severe growth retardation and facial dysmorphism, born to consanguineous normal healthy parents. Affymetrix CytoScan 750K microarray showed a 34-Mb pericentric homozygous region on chromosome 6 for both siblings. was one of the 141 genes present in this region.
View Article and Find Full Text PDFDiabetes Res Clin Pract
February 2012
Aim: The role of oxidative damage to DNA due to hyperglycemia is well known. In the current study we have evaluated the induction of micronuclei due to increased glycosylation in type 2 diabetes.
Methods: Forty-nine subjects divided into two groups of normoglycemic controls and type 2 diabetic cases were recruited in the study.