Regulation of adiponectin secretion in human subcutaneous and omental adipose tissue: effects of pioglitazone and endothelin-1: a pilot study.

Objective: The study was designed to test the effect of anti-diabetic agent pioglitazone and Endothelin-1 (ET-1) on adiponectin secretion from human adipose tissue in depot dependent manner.

Methods: Subcutaneous adipose tissue (SAT) and omental adipose tissues (OAT) were obtained from 19 subjects, including 6 non-obese controls, 7 obese and 6 obese T2DM patients. Adipose tissue was treated with pioglitazone and ET1.

Association of adiposity, inflammation and atherosclerosis: the role of adipocytokines and CRP in Asian Indian subjects.

Background: To reveal the exact link between adipose tissue, inflammation, and cardiovascular disease (CVD), we studied the association of C-reactive protein (CRP) with insulin resistance and adipocytokines in Asian Indian subjects.

Methods: Forty-one controls, 40 obese, and 53 type 2 diabetes (T2DM) patients (total 134) were recruited. Enzyme-linked immunoassay (ELISA) technique was used to determine serum CRP and adipocytokine concentrations.