Publications by authors named "Suresh Babu Nallapati"
Article Synopsis
- N-heteroarenes are important compounds in medicinal chemistry, with various synthesis methods available, particularly focusing on AlCl-mediated techniques.
- One notable reaction is the AlCl-induced heteroarylation, which offers a simpler and more efficient way to produce certain N-heteroarenes compared to traditional methods like Friedel-Crafts reactions.
- Recent advancements have introduced innovative AlCl-mediated processes that have led to the discovery of unique N-heteroarenes with promising pharmacological properties, highlighting the need for continued research in this area.
A new class of 1,2,3-triazol derivatives derived from nimesulide was designed as potential inhibitors of PDE4B. Synthesis of these compounds was carried out via a multi-step sequence consisting of copper-catalyzed azide-alkyne cycloaddition (CuAAC) as a key step in aqueous media. The required azide was prepared via the reaction of aryl amine (obtained from nimesulide) with α-chloroacetyl chloride followed by displacing the α-chloro group by an azide.
View Article and Find Full Text PDFA number of novel 1-(3-arylprop-2-ynyl) substituted 1,2-dihydroquinoline derivatives related to nimesulide and their 2-oxo analogues have been designed as potential inhibitors of PDE4. All these compounds were synthesized by using Sonogashira coupling as a key step. In vitro PDE4B inhibitory properties and molecular modeling studies of some of the compounds synthesized are presented.
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