Publications by authors named "Surendra L Soneji"
Background & Objectives: Acute myocardial infarction (AMI) is a major health concern in India. The aim of the study was to identify single nucleotide polymorphisms (SNPs) associated with AMI in patients using dedicated chip and validating the identified SNPs on custom-designed chips using high-throughput microarray analysis.
Methods: In pilot phase, 48 AMI patients and 48 healthy controls were screened for SNPs using human CVD55K BeadChip with 48,472 SNP probes on Illumina high-throughput microarray platform.
Aims/objective: Over expression of matrix degrading enzymes have been implicated in plaque destabilisation and rupture. Cathepsins associated with extracellular matrix breakdown make them intriguing suspects. The aim of the study was to analyse peripheral levels of cathepsin B and cathepsin K and their inhibitor cystatin C during acute myocardial infarction (AMI).
View Article and Find Full Text PDFPlatelet-endothelial cell adhesion molecule-1 (PECAM-1) has role in atherosclerotic plaque development as well as in thrombosis leading to myocardial infarction (MI). Present study was aimed to analyse the association of PECAM-1 Leu125Val gene polymorphism with MI in Indian population. Subjects included healthy individuals as control (N = 116) and MI patients (N = 100) divided into two groups; MI patients at presentation of the acute event (MI-Group-1, N = 46) and patients with recent event of MI stabilized with treatment 4.
View Article and Find Full Text PDFAims: To analyze soluble levels ofcell adhesion molecules (CAM) such as Intercellular CAM (ICAM), vascular CAM (VCAM-1), platelet endothelial CAM (PECAM-1), Endothelial (E)-selectin, and Platelet (P)-selectin in coronary artery disease patients and correlate with degree of severity of the disease.
Methods: Study population included patients who suffered myocardial infarction at presentation (N=49) and those with unstable angina (N=79) and stable angina (N=14). Soluble levels of CAMs were measured by ELISA.
Article Synopsis
- The study investigates the role of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) in atherosclerotic plaque, focusing on MMP-7 and MMP-8 levels in different cardiovascular conditions.
- MMP-8 levels significantly increased in acute myocardial infarction (AMI) patients but decreased in those with acute coronary syndrome (ACS), while MMP-7 was more prominent in stable angina.
- Findings suggest that MMP-8 and TIMP-2 could serve as markers for assessing vulnerable plaque in AMI, whereas MMP-7 may indicate chronic issues throughout coronary artery disease (CAD) stages.