Synthesis and Psychotropic Properties of Novel Condensed Triazines for Drug Discovery.

The exploration of heterocyclic compounds and their fused analogs, featuring key pharmacophore fragments like pyridine, thiophene, pyrimidine, and triazine rings, is pivotal in medicinal chemistry. These compounds possess a wide array of biological activities, making them an intriguing area of study. The quest for new neurotropic drugs among derivatives of these heterocycles with pharmacophore groups remains a significant research challenge.

Proton-deuterium exchange of acetone catalyzed in imidazolium-based ionic liquid-DO mixtures.

The reaction of the proton-deuterium exchange of acetone in imidazolium-based ionic liquid (IL)-deuterium oxide mixtures was studied in detail NMR spectroscopy. Certain ILs exhibit considerable catalytic properties and contribute to the course of reaction up to the complete deuteration. The efficiency of deuterium exchange crucially depends on the features of ILs; the type of anion and chain length of cation.

Derivatives of a new heterocyclic system - pyrano[3,4-][1,2,4]triazolo[4,3-]pyridines: synthesis, docking analysis and neurotropic activity.

8-Hydrazino derivatives of pyrano[3,4-]pyridines and derivatives of the new heterocyclic system 3-thioxopyrano[3,4-][1,2,4]triazolo[4,3-]pyridines on the basis of methanesulfonates of pyrano[3,4-]pyridinium were synthesized by optimization of a previously used method. Derivatives of alkylsulfonyl pyrano[3,4-][1,2,4]triazolo[4,3-]pyridines were also synthesized. All compounds were evaluated for their neurotropic activity.