Genomic diversity of the Muslim population from Telangana (India) inferred from 23 autosomal STRs.

Aim: This study aimed to investigate the genomic diversity and population structure in the Muslim community of Telangana, India, using 23 autosomal microsatellite genetic markers. We also examined genetic relatedness between Muslim and non-Muslim populations of India.

Subjects And Methods: A sample of 184 randomly selected unrelated healthy Muslim individuals from the Telangana state were included in this study.

Polymorphisms of extrinsic death receptor apoptotic genes (FAS -670 G>A, FASL -844 T>C) in coronary artery disease.

Apoptosis plays an important role in atherogenesis and rupture of vulnerable plaques in coronary artery disease. FAS and FAS ligand (FASL) induce apoptosis when FAS binds to FAS-L. However sFas blocks apoptosis by binding to FAS and FASL or sFasL.

Evaluation of Hs-CRP levels and interleukin 18 (-137G/C) promoter polymorphism in risk prediction of coronary artery disease in first degree relatives.

Background: Coronary Artery Disease (CAD) is clearly a multifactorial disease that develops from childhood and ultimately leads to death. Several reports revealed having a First Degree Relatives (FDRS) with premature CAD is a significant autonomous risk factor for CAD development. C - reactive protein (CRP) is a member of the pentraxin family and is the most widely studied proinflammatory biomarker.

Tuberculin specific T cell responses in BCG vaccinated children.

The effector mechanisms of BCG protection were examined 5-7 years after vaccination. The in vitro lymphoproliferation, following stimulation with tuberculin, in normal, (A) vaccinated and (B) unvaccinated children and children with tuberculosis (C), were assayed. The mean stimulation index (SI) of lymphocyte transformation in normal subjects were significantly (P < 0.

Cell-mediated immune responses in children towards secreted proteins of Mycobacterium bovis BCG.

Background: There is a need to develop an improved anti-TB vaccine for adequate control and elimination of tuberculosis, to control the spread of MDR-TB and TB/HIV co-infection. Studies in children have indicated that BCG vaccination has certain beneficial effects, especially against miliary TB and TB meningitis, but needs to be improved for protection against pulmonary tuberculosis.

Objective: The aim of the present study was to identify the immunogenic proteins in the culture filtrate (CF) of Mycobacterium bovis BCG by studying the effector mechanism of protection in children, which may help in the formulation of an effective vaccine against tuberculosis.