variants and their genotype-phenotype correlations in Thai patients with haemophilia A: a nationwide multicentre study.

Aims: Analysis of the gene helps predict the risk of developing factor VIII (FVIII) inhibitors and the depth of phenotype in haemophilia A (HA) patients. Since data in Southeast Asian countries remain scarce, we aim to study variation correlated with HA phenotypes in Thailand.

Methods: Thai patients with HA were enrolled from seven haemophilia treatment centres during 2022-2023.

Activation of endothelial cells, coagulation and fibrinolysis in children with Dengue virus infection.

Dengue virus causes a febrile illness: Dengue fever (DF), and less frequently a life-threatening illness: Dengue hemorrhagic fever (DHF). Although severe bleeding remains a major cause of death in DHF, the pathogenesis of bleeding is poorly understood. This prospective cohort study was designed to determine the extent of activation of endothelial cells and the hemostatic system in correlation with clinical severity, and also to detect the best prognostic factor(s) for DHF.