Publications by authors named "Surbhi Bahl"
Article Synopsis
- Leishmania secretes many effectors, but the regulation of its secretory pathway is not well understood; this study focuses on the cloning and characterization of LdRab1, a Rab1 homologue.
- LdRab1 localizes in the Golgi of Leishmania, and experiments with transgenic parasites reveal that overexpressing certain mutants of LdRab1 does not affect hemoglobin receptor trafficking but significantly inhibits the secretion of proteins like secretory acid phosphatase and Ldgp63.
- The findings indicate that while the Rab1-regulated secretory pathway is conserved in Leishmania, hemoglobin receptor trafficking operates through a different, Rab1-independent pathway.
The homotypic fusion and protein sorting (HOPS) complex is a multi-subunit complex conserved from yeast to mammals that regulates late endosome and lysosome fusion. However, little is known about how the HOPS complex is recruited to lysosomes in mammalian cells. Here, we report that the small GTPase Arl8b, but not Rab7 (also known as RAB7A), is essential for membrane localization of the human (h)Vps41 subunit of the HOPS complex.
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