Publications by authors named "Surat Saravanan"
Apical constriction powers amnioserosa contraction during Drosophila dorsal closure. The nucleation, movement and dispersal of apicomedial actomyosin complexes generates pulsed apical constrictions during early closure. Persistent apicomedial and circumapical actomyosin complexes drive unpulsed constrictions that follow.
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- - Several studies indicate that SARS-CoV-2 may cause neurological issues, but the exact mechanisms of injury to the nervous system are still not well understood.
- - The review organizes existing knowledge on COVID-19's neurological impacts using an Adverse Outcome Pathway (AOP) framework, identifying key biological events like ACE2 binding and blood-brain barrier disruption leading to issues like anosmia, encephalitis, and seizures.
- - The AOP approach highlights the role of factors such as age and stress in influencing neurological outcomes and encourages collaboration among experts from various fields to advance understanding and treatment.
How robust patterns of tissue dynamics emerge from heterogeneities, stochasticities, and asynchronies in cell behavior is an outstanding question in morphogenesis. A clear understanding of this requires examining the influence of the behavior of single cells on tissue patterning. Here we develop single-cell manipulation strategies to uncover the origin of patterned cell behavior in the amnioserosa during Drosophila dorsal closure.
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