Publications by authors named "Surasak Sawatnatee"
Whole exome sequencing and rare variant association study to identify genetic modifiers, mutations, and a novel double mutation in Thai patients with hemoglobin E/beta-thalassemia.
Chattree Hantaweepant Bhoom Suktitipat Manop Pithukpakorn Yingyong Chinthammitr Chanin Limwongse Surasak Sawatnatee
Hematology
December 2023
Article Synopsis
- Scientists studied Thai patients with Hemoglobin E/beta-thalassemia to see why some had severe symptoms while others had mild ones, even with the same genes.
- They looked at DNA samples and found 338 patients, dividing them into those with severe symptoms and those with mild symptoms for their research.
- Although they found some changes in the genes, they didn't discover any rare variants that explained the differences in how severe the illness was, but they think more research could help identify important genetic factors.
To discover new therapeutic antibodies for treatment of acute myeloid leukemia (AML) without the requirement of a known antigen, a human single-chain variable fragment (scFv) library was used to isolate novel antibody fragments recognizing HL-60 AML cells. After three rounds of biopanning, scFv-expressing phages were selected to test for binding to the target cell by flow cytometry. The clone with highest binding specificity to HL-60 cells (designated y1HL63D6) was further investigated.
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