Iron- and base-catalyzed (α)-alkylation and one-pot sequential alkylation-hydroxylation of oxindoles with secondary alcohols.

The utilization of economical and environmentally benign transition metals in crucial catalytic processes is pivotal for sustainable advancement in synthetic organic chemistry. Iron, as the most abundant transition metal in the Earth's crust, has gained significant attention for this purpose. A combination of FeCl (5 mol%) in the presence of phenanthroline (10 mol%) and NaOBu (1.

Cobalt-Catalyzed Chemodivergent Synthesis of Cyclic Amines and Lactams from Ketoacids and Anilines Using Hydrosilylation.

Here, commercially available Co(CO) was utilized as an efficient catalyst for chemodivergent synthesis of pyrrolidines and pyrrolidones from levulinic acid and aromatic amines under slightly different hydrosilylation conditions. 1.5 and 3 equiv of phenylsilane selectively yielded pyrrolidone and pyrrolidine, respectively.

Copper(i)-catalyzed click chemistry in deep eutectic solvent for the syntheses of β-d-glucopyranosyltriazoles.

In the last two decades, click chemistry has progressed as a powerful tool in joining two different molecular units to generate fascinating structures with a widespread application in various branch of sciences. copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, also known as click chemistry, has been extensively utilized as a versatile strategy for the rapid and selective formation of 1,4-disubstituted 1,2,3-triazoles. The successful use of CuAAC reaction for the preparation of biologically active triazole-attached carbohydrate-containing molecular architectures is an emerging area of glycoscience.

Cobalt catalyzed chemoselective reduction of nitroarenes: hydrosilylation under thermal and photochemical reaction conditions.

Commercially available Co(CO) was used as an effective catalyst for the hydrosilylation of nitroarenes under both thermal and photochemical conditions. A wide variety of nitroarenes with various functionalities were selectively reduced to aromatic amines. Syntheses of drug molecules expand the potential utility of this protocol.

Nickel-Catalyzed α-Alkylation of Arylacetonitriles with Challenging Secondary Alcohols.

Nickel(II) complex was utilized as a sustainable catalyst for α-alkylation of arylacetonitriles with challenging secondary alcohols. Arylacetonitriles with a wide range of functional groups were tolerated, and various cyclic and acyclic secondary alcohols were utilized to yield a large number of α-alkylated products. The plausible mechanism involves the base-promoted activation of precatalyst to an active catalyst (dehydrochlorinated product) which activates the O-H and C-H bonds of the secondary alcohol in a dehydrogenative pathway.

Manganese-Catalyzed Chemoselective Hydrosilylation of Nitroarenes: Sustainable Route to Aromatic Amines.

Herein we report efficient catalytic hydrosilylations of nitroarenes to form the corresponding aromatic amines using a well-defined manganese(II)-NNO pincer complex with a low catalyst loading (1 mol %) under solvent-free conditions. This base-metal-catalyzed hydrosilylation is an easy and sustainable alternative to classical hydrogenation. A large variety of nitroarenes bearing various functionalities were selectively transformed into the corresponding aromatic amines in good yields.

Efficient α-Alkylation of Arylacetonitriles with Secondary Alcohols Catalyzed by a Phosphine-Free Air-Stable Iridium(III) Complex.

A well-defined and readily available air-stable dimeric iridium(III) complex catalyzed α-alkylation of arylacetonitriles using secondary alcohols with the liberation of water as the only byproduct is reported. The α-alkylations were efficiently performed at 120 °C under solvent-free conditions with very low (0.1-0.

Hydrosilylation of Esters Catalyzed by Bisphosphine Manganese(I) Complex: Selective Transformation of Esters to Alcohols.

Selective and efficient hydrosilylations of esters to alcohols by a well-defined manganese(I) complex with a commercially available bisphosphine ligand are described. These reactions are easy alternatives for stoichiometric hydride reduction or hydrogenation, and employing cheap, abundant, and nonprecious metal is attractive. The hydrosilylations were performed at 100 °C under solvent-free conditions with low catalyst loading.