Introducing Our Custom GPT: An Example of the Potential Impact of Personalized GPT Builders on Scientific Writing.

Background: The rapid progression of artificial intelligence (AI) and large language models (LLMs), such as ChatGPT, has contributed to increase its utility and popularity in various fields. Discourse about AI's potential role in different aspects of scientific literature such as writing, data analysis, and literature review, is growing as the programs continue to improve their capabilities. This study utilizes a recently released ChatGPT tool that allows users to create customized GPTs to highlight the potential of customizable GPTs tailored to prepare and write research manuscripts.

Computational approaches for identifying disease-causing mutations in proteins.

Advancements in genome sequencing have expanded the scope of investigating mutations in proteins across different diseases. Amino acid mutations in a protein alter its structure, stability and function and some of them lead to diseases. Identification of disease-causing mutations is a challenging task and it will be helpful for designing therapeutic strategies.

Brain health measurement: a scoping review.

Objectives: Preservation of brain health is an urgent priority for the world's ageing population. The evidence base for brain health optimisation strategies is rapidly expanding, but clear recommendations have been limited by heterogeneity in measurement of brain health outcomes. We performed a scoping review to systematically evaluate brain health measurement in the scientific literature to date, informing development of a core outcome set.

Insights into the genotype-phenotype relationship of ocular manifestations in Kabuki syndrome.

We aim to assess if genotype-phenotype correlations are present within ocular manifestations of Kabuki syndrome (KS) among a large multicenter cohort. We conducted a retrospective, medical record review including clinical history and comprehensive ophthalmological examinations of a total of 47 individuals with molecularly confirmed KS and ocular manifestations at Boston Children's Hospital and Cincinnati Children's Hospital Medical Center. We assessed information regarding ocular structural, functional, and adnexal elements as well as pertinent associated phenotypic features associated with KS.

Drought index predictability for historical and future periods across the Southern plain of Nepal Himalaya.

Drought episodes across the Himalayas are inevitable due to rapidly increasing atmospheric temperatures and uncertainties in rainfall patterns. Tarai of Nepal is a tropical region located in the foothills of the Central Himalaya as a country's food granary with a contribution of over 50% to the entire country's agricultural production. However, there is a lack of detailed studies exploring the spatiotemporal occurrence of drought in these regions under the changing climate.

Pyridine: the scaffolds with significant clinical diversity.

The nitrogen-bearing heterocycle pyridine in its several analogous forms occupies an important position as a precious source of clinically useful agents in the field of medicinal chemistry research. This privileged scaffold has been consistently incorporated in a diverse range of drug candidates approved by the FDA (Food and Drug Administration). This moiety has attracted increasing attention from several disease states owing to its ease of parallelization and testing potential pertaining to the chemical space.

Fungal Endophytes: A Storehouse of Bioactive Compounds.

Fungal endophytes are the microbial adaptations that usually enter the plant tissues during their life cycle without harming the host plants. They are found everywhere on earth and generally depend on the hosts by developing various symbiotic relationships, like mutualism, hostility, and parasitism on rare occasions, leading to the growth and rise in the nutrient content of the hosts. Endophytes can develop tolerance in host organisms against the stresses induced by either living or non-living agents.

An Innovative Case Management and Immigrant Onboarding Model Developed by the Sharewood Project in Massachu.

The Sharewood Project, a student-run free project developed by Tufts University School of Medicine students in 1997, provides limited medical care and social services to a diverse population in Malden, Massachusetts. The project plays an unusual role in introducing immigrants to the health care and education systems in Massachusetts.

Congenital microgastria-limb reduction association: A case report and review of the literature.

We report a patient with phenotypic semblance to the congenital microgastria-limb reduction association (MLRD). Our patient presented with microgastria, bilateral upper limb anomalies, asplenia, solitary kidney, and mild micrognathia. In addition to the anomalies seen in our patient, MLRD has been associated with respiratory, cardiovascular, and central nervous system anomalies.

Copper-Catalyzed Thiolation of Terminal Alkynes Employing Thiocyanate as the Sulfur Source Leading to Enaminone-Based Alkynyl Sulfides under Ambient Conditions.

A highly efficient protocol for copper-catalyzed thio-alkynylation of enaminone-based thiocyanates with terminal alkynes under mild conditions has been developed. This scalable amino group-directed thio-alkynylation proceeds in the open air with a broad substrate scope and an excellent yield. The demonstrated synthetic transformation creates the opportunity for a wide variety of sulfur-containing useful materials.

Biomechanical Analysis Using FEA and Experiments of Metal Plate and Bone Strut Repair of a Femur Midshaft Segmental Defect.

This investigation assessed the biomechanical performance of the metal plate and bone strut technique for fixing recalcitrant nonunions of femur midshaft segmental defects, which has not been systematically done before. A finite element (FE) model was developed and then validated by experiments with the femur in 15 deg of adduction at a subclinical hip force of 1 kN. Then, FE analysis was done with the femur in 15 deg of adduction at a hip force of 3 kN representing about 4 x body weight for a 75 kg person to examine clinically relevant cases, such as an intact femur plus 8 different combinations of a lateral metal plate of fixed length, a medial bone strut of varying length, and varying numbers and locations of screws to secure the plate and strut around a midshaft defect.

Integrated Modeling and Experimental Approaches to Control Silica Modification of Design Silk-Based Biomaterials.

Mineralized polymeric biomaterials provide useful options toward mechanically robust systems for some tissue repairs. Silks as a mechanically robust protein-based material provide a starting point for biomaterial options, particularly when combined with silica toward organic-inorganic hybrid systems. To further understand the interplay between silk proteins and silica related to material properties, we systematically study the role of three key domains in bioengineered spider silk fusion proteins with respect to β-sheet formation and mineralization: (i) a core silk domain for materials assembly, (ii) a histidine tag for purification, and (iii) a silicification domain for mineralization.

Raman and Mossbauer spectroscopy and X-ray diffractometry studies on quenched copper-ferri-aluminates.

Four spinel ferrite compositions of the CuAl(x)Fe(2-x)O4, x = 0.0, 0.2, 0.

A reliable and effective method of DNA isolation from old human blood paper cards.

Blood paper cards provide an effective DNA storage method. In this study, we used three DNA dissolving reagents (Tris-EDTA [TE] buffer, Tris-HCl buffer, and water) and one common commercially available kit (DN131 from MRC Inc) to elute DNA from 105 human blood paper cards collected up to 10 years ago. These DNA samples were used as templates for amplification of a single nucleotide polymorphism (SNP, C125T) region of human caspase-12 by PCR and a specific Taqman genotyping assay using the same amount of DNA.

Biomechanical analysis using infrared thermography of a traditional metal plate versus a carbon fibre/epoxy plate for Vancouver B1 femur fractures.

Traditional high-stiffness metal plates for Vancouver B1 femur shaft fractures below the tip of a hip implant can cause stress shielding, bone resorption, and implant loosening. This is the first study to compare the biomechanics of a traditional metal plate versus a low-stiffness carbon fibre/epoxy composite plate for this injury. A total hip replacement was implanted in two previously validated intact artificial femurs.

The biomechanics of three different fracture fixation implants for distal femur repair in the presence of a tumor-like defect.

The femur is the most common long bone involved in metastatic disease. There is consensus about treating diaphyseal and epiphyseal metastatic lesions. However, the choice of device for optimal fixation for distal femur metaphyseal metastatic lesion remains unclear.

The biomechanical effect of proximal tumor defect location on femur pathological fractures.

Objectives: The femur is the most common long bone affected by cancerous metastasis. Femoral tumor defects are known to induce pain and functional impairment in patients. Although prior studies exist evaluating the clinical and biomechanical effect of tumor defect size, no biomechanical studies have experimentally examined the risk of pathological fracture with respect to the anterior, posterior, medial, and lateral surfaces on which a proximal tumor defect is located on the femur.

Biomechanical properties of an intact, injured, repaired, and healed femur: an experimental and computational study.

There is no "gold standard" treatment for femoral mid-shaft fractures near the tip of a hip implant. Moreover, no study has quantified the changes in a femur's mechanical properties from injury through to healing. The present aim was to predict overall stiffness and peak bone stress in the same femur after injury, repair, and healing with respect to its intact condition.

A biomechanical comparison of static versus dynamic lag screw modes for cephalomedullary nails used to fix unstable peritrochanteric fractures.

Background: The gamma nail has an option to statically lock its lag screw (static mode) or to allow its lag screw to move within the nail to compress the intertrochanteric fracture (dynamic mode). The purpose of this study was to compare the biomechanical stiffness of static and dynamic lag screw modes for a cephalomedullary nail used to fix an unstable peritrochanteric fracture.

Methods: Unstable four-part peritrochanteric fractures were created in 30 synthetic femurs and fixed with Long Gamma 3 Nails.

Biomechanical stress maps of an artificial femur obtained using a new infrared thermography technique validated by strain gages.

Femurs are the heaviest, longest, and strongest long bones in the human body and are routinely subjected to cyclic forces. Strain gages are commonly employed to experimentally validate finite element models of the femur in order to generate 3D stresses, yet there is little information on a relatively new infrared (IR) thermography technique now available for biomechanics applications. In this study, IR thermography validated with strain gages was used to measure the principal stresses in the artificial femur model from Sawbones (Vashon, WA, USA) increasingly being used for biomechanical research.

Femoral head lag screw position for cephalomedullary nails: a biomechanical analysis.

Objectives: The purpose of this study was to determine if lag screw position affects the biomechanical properties of a cephalomedullary nail used to fix an unstable peritrochanteric fracture.

Methods: Unstable peritrochanteric fractures were created in 30 synthetic femurs and repaired with Long Gamma 3 Nails using one of 5 lag screw positions: superior, inferior, anterior, posterior, or central. Radiographic measurements including tip-apex distance and a calcar referenced tip-apex distance were calculated from anteroposterior and lateral radiographs.

A preliminary biomechanical assessment of a polymer composite hip implant using an infrared thermography technique validated by strain gage measurements.

With the resurgence of composite materials in orthopaedic applications, a rigorous assessment of stress is needed to predict any failure of bone-implant systems. For current biomechanics research, strain gage measurements are employed to experimentally validate finite element models, which then characterize stress in the bone and implant. Our preliminary study experimentally validates a relatively new nondestructive testing technique for orthopaedic implants.

A preliminary biomechanical study of a novel carbon-fibre hip implant versus standard metallic hip implants.

Total hip arthroplasty is a widespread surgical approach for treating severe osteoarthritis of the human hip. Aseptic loosening of standard metallic hip implants due to stress shielding and bone loss has motivated the development of new materials for hip prostheses. Numerically, a three-dimensional finite element (FE) model that mimicked hip implants was used to compare a new hip stem to two commercially available implants.