Publications by authors named "Suraj S Shetty"
Sexual dimorphism plays a vital role in individual identification, and body dimensions can contribute to establishing a biological profile for identification purposes. To determine the reliability of the Heel-Ball Index (HBI) in estimating sex from foot dimensions and footprint dimensions and also to investigate the potential of dimensions and indices, using a standardized value, in estimating sex, from foot dimensions and footprint dimensions. In this study, a group of 112 young Indian adults aged 18 to 22, consisting of 56 males and 56 females, was examined.
View Article and Find Full Text PDFThe mouse is a useful preclinical species for evaluating disease etiology due to the availability of a wide variety of genetically modified strains and the ability to perform disease-modifying manipulations. In order to establish an atrial filtration (AF) model in our laboratory, we profiled several commonly used murine AF models. We initially evaluated a pharmacological model of acute carbachol (CCh) treatment plus atrial burst pacing in C57BL/6 mice.
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- Endothelin-1 (ET-1) is a key molecule involved in regulating blood vessel function and is primarily produced by endothelial cells, interacting with two receptor types, ETA and ETB.
- The study developed and tested a new compound, CGS 31398, which shows strong ability to bind to both ETA and ETB receptors, with very low inhibition concentrations for both types in lab settings.
- However, in live rats, CGS 31398 unexpectedly increased the constricting response of blood vessels to ET-1, suggesting that while it's effective in binding, its real-world effects vary significantly, indicating potential weaknesses in ETA receptor antagonism.