Formulation development and evaluation of nasal gel of promethazine hydrochloride.

Objective: The present work aims to develop mucoadhesive thermosensitive nasal gel for Promethazine hydrochloride using quality by design (QbD) approach. It can reduce nasal mucociliary clearance (MCC) and increase residence of the drug on nasal mucosa. This might increase drug absorption to improve bioavailability of the drug as compared to oral dosage form.