The gut microbe pair of sp. GMB0313 and sp. GMB0270 confers complete protection against SARS-CoV-2 infection by activating CD8+ T cell-mediated immunity.

Despite the potential protective role of the gut microbiome against COVID-19, specific microbes conferring resistance to COVID-19 have not yet been identified. In this work, we aimed to identify and validate gut microbes at the species level that provide protection against SARS-CoV-2 infection. To identify gut microbes conferring protection against COVID-19, we conducted a fecal microbiota transplantation (FMT) from an individual with no history of COVID-19 infection or immunization into a lethal COVID-19 hamster model.

Nectandrin B significantly increases the lifespan of - Nectandrin B for longevity.

Phytochemicals are increasingly recognized in the field of healthy aging as potential therapeutics against various aging-related diseases. Nutmeg, derived from the tree, is an example. Nutmeg has been extensively studied and proven to possess antioxidant properties that protect against aging and alleviate serious diseases such as cancer, heart disease, and liver disease.

Oral delivery of a host-directed antiviral, niclosamide, as a cholate-coated nanoformulation.

Potentially significant drug candidates often face elimination from consideration due to the lack of an effective method for systemic delivery. The poor solubility of these candidates has posed a major obstacle for their development as oral pills or injectables. Niclosamide, a host-directed antiviral, is a good example.

The Related Mechanisms Predicted through Network-Based Pharmacological Analysis and the Anti-Inflammatory Effects of Hance Bark on Contact Dermatitis in Mice.

Hance bark has been used to treat patients with inflammatory or purulent skin diseases in China, Japan, and Korea. This study was undertaken to determine the mechanism responsible for the effects of and whether it has a therapeutic effect in mice with contact dermatitis (CD). In this study, the active compounds in , their targets, and target gene information for inflammatory dermatosis were investigated using network-based pharmacological analysis.

Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice.

Objective: To investigate the anti-inflammatory potential of Ampelopsis japonica on contact dermatitis (CD).

Methods: A total of 38 Balb/c mice were divided into 5 groups by using a random number table: normal mice (n=6), CD model mice (n=8), CD mice treated with 3 or 30 mg/kg of the ethanol extract of A. japonica (EEAJ, n=8) and 7.

Reactive Polymer Targeting dsRNA as Universal Virus Detection Platform with Enhanced Sensitivity.

Reactive poly(pentafluorophenyl acrylate) (PPFPA)-grafted surfaces offer a versatile platform to immobilize biomolecules. Here, we utilize PPFPA-grafted surface and double-stranded RNA (dsRNA) recognizing J2 antibody to construct a universal virus detection platform with enhanced sensitivity. PPFPA on silicon substrates is prepared, and surface hydrophilicity is modulated by partial substitution of the pentafluorophenyl units with poly(ethylene glycol).

Gentiana scabra Bunge roots alleviates skin lesions of contact dermatitis in mice.

Ethnopharmacological Relevance: The roots and rhizomes of Gentiana scabra Bunge in the family Gentianaceae comprise a major herbal medicine for skin diseases caused by wind-heat or dampness-heat in China, Japan and Korea. This treatment can clear away heat and dry dampness and purge fire from the liver and gallbladder.

Aim Of The Study: This study was designed to investigate the therapeutic potential and anti-inflammatory effects of G.

Preparation of Poly(pentafluorophenyl acrylate) Functionalized SiO2 Beads for Protein Purification.

We demonstrate a simple method to prepare poly(pentafluorophenyl acrylate) (poly(PFPA)) grafted silica beads for antibody immobilization and subsequent immunoprecipitation (IP) application. The poly(PFPA) grafted surface is prepared via a simple two-step process. In the first step, 3-aminopropyltriethoxysilane (APTES) is deposited as a linker molecule onto the silica surface.

Decoction of Turcz. Root Bark Ameliorates Skin Lesions and Inhibits Inflammatory Reactions in Mice with Contact Dermatitis.

Background: The root bark of Turcz. (Dictamni Radicis Cortex) has been widely used to treat skin diseases in Korea, and its anti-inflammatory efficacies were recently reported.

Objective: The paper aims to investigate the inhibitory effects of decoction of Dictamni Radicis Cortex (DDRC) in mice with contact dermatitis (CD).

Fixed-volume metering microdispenser module.

In this work, we present a novel fixed-volume metering microdispenser module using the sPROMs (structurally programmable microfluidic systems) technology. We have designed, simulated, fabricated and characterized an array of microdispensers with volumes ranging from 50 nL [nanoliter] to 150 nL. We have characterized several key components of the microdispenser, such as passive microvalves and the air-driven liquid column splitting process, using extensive simulations.