cAMP-dependent recruitment of acidic organelles for Ca2+ signaling in the salivary gland.

Autonomic neural activation of intracellular Ca release in parotid acinar cells induces the secretion of the fluid and protein components of primary saliva critical for maintaining overall oral homeostasis. In the current study, we profiled the role of acidic organelles in shaping the Ca signals of parotid acini using a variety of imaging and pharmacological approaches. Results demonstrate that zymogen granules predominate as an apically polarized population of acidic organelles that contributes to the initial Ca release.

Internal jugular vein hemangioma.

Primary tumors of the major body veins arising intraluminally are rare clinical entities. As such, few cases have been reported in the literature. As a primary tumor, hemangiomas arising in the internal jugular vein are extremely rare, while those arising in the external jugular vein are only slightly more common.

Occupational silica exposure as a risk factor for scleroderma: a meta-analysis.

Objectives: Among potential environmental risk factors for systemic sclerosis (SSc), occupational exposures have received some attention. In this meta-analysis, we examined the association between SSc and occupational exposure to silica.

Methods: We searched Medline, Toxline, BIOSIS, and Embase (1949 and November 2009) for original articles published in any language.