A comprehensive approach to prediction of fractional flow reserve from deep-learning-augmented model.

The underuse of invasive fractional flow reserve (FFR) in clinical practice has motivated research towards non-invasive prediction of FFR. Although the non-invasive derivation of FFR (FFR) using computational fluid dynamics (CFD) principles has become a common practice, its clinical application has been limited due to the considerable time required for computation of resulting changes in haemodynamic conditions. An alternative to CFD technology is incorporating a neural network into the computational process to reduce the time necessary for running an effective model.

Numerical study of hemodynamic changes in the Circle of Willis after stenosis of the internal carotid artery.

Background And Objectives: In clinical practice a large number of patients with ischemic stroke have internal carotid artery (ICA) stenosis accompanied by Circle of Willis (CoW) stenosis. In the presence of carotid artery stenosis, CoW atherosclerosis may cause cerebral blood flow decompensation and may promote the development of ischemic stroke. The reason for the concomitant stenosis at both sites is unknown.

A high-fidelity geometric multiscale hemodynamic model for predicting myocardial ischemia.

Background And Objectives: Coronary computed tomography angiography (CCTA) derived fractional flow reserve (CT-FFR) requires a maximal hyperemic state to be modeled by assuming the total coronary resistance decreased to a constant 0.24 of that under the resting state. However, this assumption neglects the vasodilator capacity of individual patients.

Comparison of the Effects of Acute Appendicitis and Chronic Cholecystitis on Intestinal Mucosal Function During Surgery.

Objective: The objective of this study is to explore the effect of acute appendicitis and chronic cholecystitis on inflammatory factors and intestinal mucosal function during operation.

Methods: This was a prospective cohort study. Forty-four patients including those who underwent elective cholecystectomy (Group A, n = 22) or emergency appendectomy (Group B, n = 22) were recruited.

A computer model of the effect of venous-arterial-venous extracorporeal membrane oxygenation venous return of oxygenated blood on right atrial recirculation and tricuspid valve blood oxygen saturation.

Objective: Venous-arterial venous extracorporeal membrane oxygenation (V-AV ECMO), as a new clinical application of ECMO, showed great clinical application potential in the treatment of patients with combined cardiopulmonary failure. Given the complicated cannulation strategy of V-AV ECMO, its influence on the hemodynamics of the human circulatory system remained unclear.

Methods: In this paper, a fluid-structure interaction was used to study the effect of V-AV ECMO oxygenated blood shunt ratio on right atrial recirculation and tricuspid valve (TV) blood oxygen saturation.

On inlet pressure boundary conditions for CT-based computation of fractional flow reserve: clinical measurement of aortic pressure.

Background And Objectives: A quick calculation approach of steady-state fractional flow reserve (FFRss) based on computed tomography angiography (CTA) images is a reliable non-invasive way of calculate FFR, the assumptions used in the research should be study further to increase forecast accuracy. The effect of inlet and outlet boundary conditions on FFRss was investigated.

Methods: 15 patients who had been diagnosed with coronary artery disease were enrolled in this study.

Non-Invasive Quantification of Fraction Flow Reserve Based on Steady-State Geometric Multiscale Models.

The underuse of invasive fraction flow reserve (FFR) in clinical practice has motivated research towards its non-invasive prediction. The early attempts relied on solving the incompressible three-dimensional Navier-Stokes equations in segmented coronary arteries. However, transient boundary condition has a high resource intensity in terms of computational time.

Effect of the Coronary Arterial Diameter Derived From Coronary Computed Tomography Angiography on Fractional Flow Reserve.

Background: Fractional flow reserve (FFR) is considered to be the criterion standard for the clinical diagnosis of functional myocardial ischemia. In this study, we explored the effect of the coronary arterial diameter derived from coronary computed tomography angiography on FFR.

Method: We retrospectively reviewed the clinical information of 131 patients with moderate coronary artery stenosis.

Highly-efficient red-to-yellow/green upconversion sensitized by phthalocyanine palladium with high triplet energy-level.

Soluble 3,7,11,15-tetra(-butyl)phthalocyanine palladium (TBPcPd) and 3,7,11,15-tetra(pentyloxy)phthalocyanine palladium (POPcPd) were synthesized and employed as sensitizers in expectation of achieving red-to-yellow/green upconversion (UC), doped with rubrene (Rub) and 9,10-bis(phenylethynyl)anthracene (BPEA), respectively. Under excitation of a 655 nm diode laser (∼1.5 W cm), a maximum red-to-green UC efficiency of 0.

Hemodynamics study on the relationship between the sigmoid sinus wall dehiscence and the blood flow pattern of the transverse sinus and sigmoid sinus junction.

Sigmoid sinus wall dehiscence (SSWD) is a common pathophysiology of patients with pulsatile tinnitus (PT). However, the pathological mechanism of SSWD is unclear. This study aimed to investigate the relationship between the position of the SSWD and blood flow pattern of the transverse sinus and sigmoid sinus (TS-SS) junction.

The Median Effective Concentration (EC) of Epidural Ropivacaine With Different Doses of Oxycodone During Limb Surgery in Elderly Patients.

Background: Oxycodone can be used both intravenously and epidurally in elderly patients because of its strong analgesic effect and more slight respiratory inhibition compared with other opioids at the same effect. In this study, we determined the median effective concentration (EC) of epidural ropivacaine required for great saphenous vein surgery in elderly patients in order to describe its pharmacodynamic interaction with oxycodone.

Methods: One hundred forty-one elderly patients scheduled for high ligation and stripping of the great saphenous vein surgery were allocated into three groups in a randomized, double-blinded manner as follows: Q2.

Hemodynamic mechanism of pulsatile tinnitus caused by venous diverticulum treated with coil embolization.

Background And Objective: Coil embolization has become a new treatment method for pulsatile tinnitus (PT) caused by sigmoid sinus diverticulum (SSD). Although this therapy has achieved good results in clinical reports, the hemodynamic mechanism of coils in the treatment of PT in SSD remained unclear.

Methods: Finite element method (FEM) and computational fluid dynamics (CFD) were combined to explore the hemodynamic mechanism of coil embolization in SSD treatment.

Hemodynamic study of the therapeutic effects of the different degrees of sigmoid sinus diverticulum reconstruction on patients.

Sigmoid sinus diverticulum (SSD) is a common pathophysiology of pulsatile tinnitus (PT) and mainly treated by SSD reconstruction surgery. The degree of reconstruction is an important indicator of SSD reconstruction surgery, but its impact on the effect of SSD reconstruction is unclear. This study aimed to clarify the effect of the degree of SSD reconstruction on diverticulum reconstruction surgical treatment.

New species and new synonyms of Macromotettixoides (Orthoptera: Tetrigidae) with an updated key.

The genus Macromotettixoides Zheng, Wei Jiang, 2005 is reviewed. Four new species of the genus, M. daiyunshanensis Deng, sp.

A stimuli responsive triplet-triplet annihilation upconversion system and its application as a ratiometric sensor for Fe ions.

A ratiometric fluorescent sensor for the detection of Fe ions is achieved based on triplet-triplet annihilation upconversion (TTA-UC) luminescence. A new anthracene derivative (named as DHTPA) is designed and synthesized and reveals similar optical properties to 9,10-diphenylanthracene (DPA) and is used as a stimuli responsive annihilator in a TTA-UC system due to its complexation ability. As a result, the UC emission can be significantly quenched by Fe ions, while the phosphorescence (PL) emission of sensitizer palladium(ii) octaetylporphyrin (PdOEP) remains nearly constant, which makes the PL signal an appropriate internal reference for the UC signal.

Can Dexmedetomidine Improve Arterial Oxygenation and Intrapulmonary Shunt during One-lung Ventilation in Adults Undergoing Thoracic Surgery? A Meta-analysis of Randomized, Placebo-controlled Trials.

Background: One-lung ventilation (OLV) is a common ventilation technology during thoracic surgery that can cause serious clinical problems. We aimed to conduct a meta-analysis to compare oxygenation and intrapulmonary shunt during OLV in adults undergoing thoracic surgery with dexmedetomidine (Dex) versus placebo to assess the influence and safety of using Dex.

Methods: Randomized controlled trials comparing lung protection in patients who underwent thoracic surgery with Dex or a placebo were retrieved from PubMed, EMBASE, MEDLINE, Cochrane Library, and China CNKI database.

Cancer survival in China, 2003-2005: a population-based study.

Limited population-based cancer registry data available in China until now has hampered efforts to inform cancer control policy. Following extensive efforts to improve the systematic cancer surveillance in this country, we report on the largest pooled analysis of cancer survival data in China to date. Of 21 population-based cancer registries, data from 17 registries (n = 138,852 cancer records) were included in the final analysis.

The influence of the severity of chronic virus-related liver disease on propofol requirements during propofol-remifentanil anesthesia.

Purpose: The purpose of this study was to investigate the influence of chronic virus- related liver disease severity on propofol requirements.

Materials And Methods: In this study, 48 male patients with chronic hepatitis B infection were divided into three groups according to Child-Turcotte-Pugh classification of liver function (groups A, B, and C with mild, moderate and severe liver disease, respectively). After intubation, propofol concentration was adjusted by ± 0.

Do the lungs contribute to propofol elimination in patients during orthotopic liver transplantation without veno-venous bypass?

Background: The clearance of propofol is very rapid, and its transformation takes place mainly in the liver. Some reports indicated extrahepatic clearance of the drug and that the lungs are the likely place where the process occurs. This study was undertaken to compare the plasma concentrations of propofol both in the pulmonary and radial arteries after constant infusion during the dissection, anhepatic and reperfusion phases of orthotopic liver transplantation (OLT) without veno-venous bypass, attempting to investigate extrahepatic clearance and to determine whether the human lungs take part in the elimination of propofol.

Plasma levels of tumor necrotic factor-alpha and interleukin-6, -8 during orthotopic liver transplantation and their relations to postoperative pulmonary complications.

Background: Pulmonary complications after orthotopic liver transplantation (OLT) include high morbidity and mortality. Experimental data have suggested hepatic ischemia and reperfusion are induced by pro-inflammatory cytokines. The high level of inflammatory cytokines might additionally influence pulmonary capillary fluid filtration.