Prospective therapeutic targets and recent advancements in the treatment of inflammatory bowel disease.

Objective: Inflammatory Bowel Disease (IBD) poses a persistent challenge in the realm of gastroenterology, necessitating continual exploration of innovative treatment strategies. The limited efficacy and potential side effects associated with existing therapeutic modalities underscore the urgent need for novel approaches in IBD management. This study aims to examine potential therapeutic targets and recent advancements in understanding the disease's intricate pathogenesis, with a spotlight on the gut microbiome, immune dysregulation, and genetic predispositions.

Correction to "Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives".

[This corrects the article on p. 2078 in vol. 29, PMID: 37122604.

Crisaborole loaded nanoemulgel for the mitigation of atopic dermatitis in mice model.

Objective: The present work aims to formulate nanoemulgel of crisaborole (CB) and evaluate its effectiveness against 2,4-Di-nitrochlorobenzene induced (DNCB) atopic dermatitis (AD) in mice.

Significance: AD is a chronic inflammation of the skin affecting the quality of life. CB is a topical PDE4 inhibitor marketed as a 2% ointment.

Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives.

Experimental evidence supports the fact that changes in the bowel microflora due to environmental or dietary factors have been investigated as implicating factors in the etiopathogenesis of inflammatory bowel disease (IBD). The amassing knowledge that the inhabited microbiome regulates the gut physiology and immune functions in IBD, has led researchers to explore the effectiveness of prebiotics, probiotics, and synbiotics in treating IBD. This therapeutic approach focuses on restoring the dynamic balance between the microflora and host defense mechanisms in the intestinal mucosa to prevent the onset and persistence of intestinal inflammation.

Somatic Embryogenesis of Anthurium andraeanum Linden., -A Tropical Florists' Plant.

The global floriculture market is expected to reach US$41.1 billion by 2027 at a CAGR of 5% over the analysis period 2020-2027; on the year 2020, the recorded market value in this trade was US$29.2 billion.

Drug Repurposing: An Emerging Tool for Drug Reuse, Recycling and Discovery.

Drug repositioning or repurposing is a revolutionary breakthrough in drug development that focuses on rediscovering new uses for old therapeutic agents. Drug repositioning can be defined more precisely as the process of exploring new indications for an already approved drug while drug repurposing includes overall re-development approaches grounded in the identical chemical structure of the active drug moiety as in the original product. The repositioning approach accelerates the drug development process, curtails the cost and risk inherent to drug development.

Rich phase transitions in strongly confined polymer-nanoparticle mixtures: Nematic ordering, crystallization, and liquid-liquid phase separation.

We investigate the rich phase behavior of strongly confined semi-flexible (SFC) polymer-nanoparticle (NP) systems using the graphics processing unit accelerated Langevin dynamics simulation. Hard nanoparticles (HNP) that repel each other and ideal nanoparticles (INP) that do not interact with the same species are used as model additives to a strongly confined semiflexible polymer fluid. Both types of NPs exclude the monomer beads in the same way, but they have qualitatively different effects on the SFC isotropic-nematic (I-N) transition.

Role of divalent cation (Ba) substitution in the Li ion conductor LiTi(PO): a molecular dynamics study.

The derivatives of LiTi2(PO4)3 are promising electrolytes for solid-state batteries. An extensive molecular dynamics study is performed employing a refined set of potential parameters to understand the influence of Ba substitution on Li+ ion conductivity in Bax/2Li1-xTi2(PO4)3 (0.0 ≤ x ≤ 0.

Investigation of nematic to smectic phase transition and dynamical properties of strongly confined semiflexible polymers using Langevin dynamics.

We investigated the nematic to smectic phase transition for strongly confined semiflexible polymer solutions in slit-like confinements using GPU-accelerated Langevin dynamics. We characterized the phase transitions from the nematic to smectic phases for semi-flexible polymer solutions as the polymer density increased. The dependence for the lyotropic nematic to smectic transition can be collapsed by scaling exponents between 0.

Influence of Si/P ordering on Na+ transport in NASICONs.

The influence of Si/P ordering on Na(+) transport in the high conducting NASICON composition, Na3Zr2Si2PO12, is investigated using molecular dynamics simulation. The study demonstrates that the Na(+) conductivity in the system changes by more than an order of magnitude depending on the Si/P order in the structure. This rather surprising observation is attributed to the modulations in the electrostatic potential energy landscape along the conduction channel originating out of the increased coulombic repulsion of Na(+) with P(5+) ions compared to Si(4+).