Publications by authors named "Supriti Ghosh"
Article Synopsis
- Aberrant DNA methylation is key in the development of oral cancer, with previous findings showing hypermethylation of specific gene promoters in patients with tongue squamous cell carcinoma compared to normal samples.
- The study involved analyzing saliva and tissue samples from normal, premalignant, and cancerous subjects to assess the methylation status of four candidate genes, utilizing advanced sequencing and computational methods for evaluation.
- Results indicated that hypermethylation of DAPK1, LRPPRC, RAB6C, and ZNF471 was present in both premalignant and malignant samples, with a strong correlation between saliva and tissue methylation levels, leading to a classifier that effectively distinguished between tumors and normal tissues.
Cervical cancer is preventable yet one of the most prevalent cancers among women around the globe. Though regular screening has resulted in the decline in incidence, the disease claims a high number of lives every year, especially in the developing countries. Owing to rather aggressive and non-specific nature of the conventional chemotherapeutics, there is a growing need for newer treatment modalities.
View Article and Find Full Text PDFBackground: Reproductive well-being is a crucial element of women's health. Due to the asymptomatic nature of gynaecological morbidities, women rarely seek medical advice in the initial period leading to delayed diagnosis and poor prognosis of subsequent disease. The present study aimed to explore the cervical cytology and its associated risk factors among women from tribal communities of the southern part of coastal Karnataka, India.
View Article and Find Full Text PDFArticle Synopsis
- Cervical cancer is a major health issue for women in India, particularly among tribal communities in coastal Karnataka, where awareness and screening are lacking despite the availability of methods to detect the disease.
- A study involving 1,140 women aged 20-65 revealed that while most had heard of cervical cancer, only a small percentage knew it could be prevented or detected early, and none had undergone screening.
- The findings highlight a significant gap in knowledge about cervical cancer, indicating a need for targeted health education and organized screening programs to improve awareness and encourage preventive measures among these women.
Article Synopsis
- Cervical cancer remains a significant health issue despite being preventable, with HPV and other viral infections influencing cervical dysplasia, particularly in southern coastal Karnataka, India.
- A study surveyed 2,240 women (1,140 tribal and 1,100 from the general population) to assess the prevalence of cervical infections using advanced techniques like PCR and DNA sequencing.
- Findings revealed a higher HPV prevalence in tribal women (40.6%) compared to the general population (14.3%), while EBV and CMV were more common in the general population; the study also noted specific risk factors and urged further research on the interactions between multiple viral infections and cancer development.
Epigenomics encompasses the study of genome-wide changes in DNA methylation, histone modifications and noncoding RNAs leading to altered transcription, chromatin structure, and posttranscription RNA processing, respectively, resulting in an altered rate of gene expression. The role of epigenetic modifications facilitating human diseases is well established. Previous studies have identified histone and cytosine code during normal and pathological conditions with special emphasis on how these modifications regulate transcriptional events.
View Article and Find Full Text PDFBackground: The human papillomavirus (HPV) and its variants show wide geographical distribution and have been reported to cause cervical lesions. With cervical neoplasia as the leading cancer in Indian women, the aim of the present study was to evaluate the multiple infection HPV type distribution and variant genotypes in cervical samples from the coastal Karnataka region, India.
Materials And Methods: A total of 212 samples were screened by nested polymerase chain reaction using PGMY9/11 and GP5+/6+ primers.