Copper phthalate coordination polymers incorporating kinked dipyridyl ligands: an unprecedented 8-connected network and one-dimensional chiral nanobarrels with hydrophobic channels constructed from septuple helical motifs.

Copper phthalate coordination polymers incorporating the kinked and hydrogen-bonding-capable imines 4,4'-dipyridylketone (dpk) and 4,4'-dipyridylamine (dpa) have been prepared and structurally characterized by single-crystal X-ray diffraction. {[Cu(pht)(dpk)].0.

A chiral luminescent coordination polymer featuring a unique 4-connected self-catenated topology built from helical motifs.

The luminescent chiral coordination polymer {[Cd(pht)(dpa)(H(2)O)] x 4 H(2)O}(n) (pht = phthalate; dpa = 4,4'-dipyridylamine) possesses an unprecedented 4-connected uninodal self-catenated three-dimensional 7(4)8(2) network topology, constructed from the interlocking of [Cd(dpa)](n) double helices with [Cd(pht)](n) single helices.

Cadmium dicarboxylate coordination polymers incorporating a long-spanning organodiimine: in situ alkene isomerization and an unprecedented chiral 6(5)8 two-dimensional network.

Reaction of cadmium nitrate, maleic acid, and N,N'-bis(4-pyridylmethyl)piperazine (bpmp) in a methanol/water mixed solvent system at 25 degrees C resulted in an unexpected in situ isomerization and formation of [[Cd(fumarate)(bpmp)(H2O)2] x 2H2O]n (1), which exhibits a system of mutually interpenetrated [Cd(fumarate)(bpmp)(H(2)O)]n grid-like coordination polymer layers. A similar reaction using cadmium chloride and succinic acid produced [[Cd(succinate)(bpmp)(CH3OH)] x 2H2O]n (2), which manifests a chiral two-dimensional coordination polymer network with an unprecedented 6(5)8 topology. The differences in the conformations of the four-carbon dicarboxylate tethers (anti in , gauche in ) and cadmium coordination environment (octahedral in , pentagonal bipyramidal in ) play a significant role in structure direction during self-assembly.

Self-catenated and interdigitated layered coordination polymers constructed from kinked dicarboxylate and organodiimine ligands.

Hydrothermal combination of divalent nickel or cobalt nitrates with the kinked carboxylic acid 4,4'-oxybis(benzoic acid) (H2oba) and the kinked and hydrogen-bonding capable organodiimine 4,4'-dipyridylamine (dpa) under basic conditions has afforded a pair of coordination polymers with a formulation of {[M(oba)(dpa)] x H2O} (M = Ni, 1; M = Co, 2). Both materials were characterized by single-crystal X-ray diffraction, infrared spectroscopy, and thermogravimetric analysis. The structures of 1 and 2 are isomorphous and manifest intriguing self-catenated two-dimensional layered motifs with very rare non-diamond 66 topology constructed from the direct covalent linkage of [M(oba)]n double helices through [M(dpa)]n undulating chains.

Diverse entangled metal-organic framework materials incorporating kinked organodiimine and flexible aliphatic dicarboxylate ligands: synthesis, structure, physical properties, and reversible structural reorganization.

Hydrothermal synthesis has afforded a family of divalent metal adipate (adp) coordination polymers incorporating the kinked dipodal organodiimine 4,4'-dipyridylamine (dpa). As revealed by single-crystal X-ray diffraction, the structures of these materials are critically dependent on the metal coordination geometry, the carboxylate binding modes, and the conformations of the flexible adipate moieties. In all cases, hydrogen-bonding interactions imparted by the dpa tethers also play a structure-directing role.

Eu(III) macrocyclic complexes promote cleavage of and bind to models for the 5'-cap of mRNA. Effect of pendent group and a second metal ion.

The interaction of three Eu(III) macrocyclic complexes Eu(THED)3+, Eu(ATHC)3+, and Eu(ATHC)3+, and Eu(S-THP)3+ with two 5'-cap model compounds, GpppG and m7GpppG is studied (THED = 1,4,7,10-tetrakis(2-hydroxyethyl)-1,4,7,-10-tetraazacyclododecane, ATHC = 1-(carbamoylmethyl)-4,7,10-tris(2-hydroxyethyl)-1,4,7,10- tetraazacyclododecane, S-THP = 1S,4S,7S,10S-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane). Laser-induced excitation luminescence spectroscopy is used to study the binding of Eu(S-THP)3+ to GpppG (K = 5.9 x 10(4) M-1) and to characterize the Eu(S-THP)-GpppG complex.

The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates.

MS-325 is a novel blood pool contrast agent for magnetic resonance imaging currently undergoing clinical trials to assess blockage in arteries. MS-325 functions by binding to human serum albumin (HSA) in plasma. Binding to HSA serves to prolong plasma half-life, retain the agent in the blood pool, and increase the relaxation rate of water protons in plasma.

Displacement of Inner-Sphere Water Molecules from Eu(3+) Analogues of Gd(3+) MRI Contrast Agents by Carbonate and Phosphate Anions: Dissociation Constants from Luminescence Data in the Rapid-Exchange Limit.

Europium(III) (7)F(0) --> (5)D(0) excitation spectroscopy is used to determine if the anions carbonate and phosphate present in physiological fluids are able to displace water molecules from the first coordination sphere of Eu(3+) analogues of Gd(3+) MRI contrast agents. A lengthening of the Eu(3+) excited state lifetime in the presence of millimolar concentrations of carbonate or phosphate indicates that water molecules are displaced by an anion. Only those metal complexes that contain negatively charged ligands and more than one water molecule in the first coordination sphere of Eu(3+) have their water molecules displaced by saturating concentrations of carbonate or phosphate.