Publications by authors named "Suping Zou"
Sirtuin 1 (SIRT1), an NAD-dependent protein deacetylase, plays a central role in the control of lipid metabolism in nonruminants. However, the role of SIRT1 in hepatic lipid metabolism in dairy cows with fatty liver is not well known. Thus, we used isolated primary bovine hepatocytes to determine the role of SIRT1 in protecting cells against oleic acid (OA)-induced steatosis.
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- Dairy cows often face negative energy balance and fatty liver issues around calving, affecting their health during this critical period.
- A study compared control cows and those with mild fatty liver, observing higher cholesterol and triglycerides in the fatty liver group, along with increased lipid synthesis proteins and decreased fatty acid oxidation proteins.
- The findings suggest that hepatic steatosis disrupts liver lipid metabolism by enhancing lipid synthesis while impairing the body's ability to oxidize fats, potentially leading to further health complications in dairy cows.
The current study aimed at investigating the effects of flavonoids from (FAC) on the proliferation, the contents, and gene expression levels of cytokines, secretion of surface stimulating factors, cell cycle, and the expression level of the NF-B signalling pathway in RAW264.7 cells. Our results revealed that compared with control group, the contents of IL-6, IL-1, TNF-, and NO and the mRNA expression levels of IL-6, IL-1, TNF-, and iNOS in FAC-treated groups significantly increased ( < 0.
View Article and Find Full Text PDFThe present study was designed to investigate the effects of Astragaloside IV (ASIV) on the immune functions of RAW264.7 cells. Compared with control group, the concentrations of interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α) and nitric oxide (NO) were higher in the 100μg/mL ASIV-treatment group.
View Article and Find Full Text PDF[The evaluation of four-year highly active antiretroviral therapy in HIV-1 infected patients].
Zhonghua Nei Ke Za Zhi
March 2011
Objective: To observe that antiretroviral efficacy, immune reconstitution of four-year highly active antiretroviral therapy (HAART), and evaluate its side effect in Chinese HIV-1-infected patients.
Methods: A total of 258 HIV-1 infected patients, given HAART regimens composed of two nucleoside reverse transcriptase inhibitor (NRTI) and one non-nucleoside reverse transcriptase inhibitor (NNRTI) for mean 51.5 months, measured HIV RNA viral load (VL) and the counts of CD(4)(+) T cell, CD(8)(+) T cell at the baseline and 6, 12, 24, 36 and 48 months after HAART initiation, respectively, monitoring side effect, blood routine, main biochemical parameters, and other disadvantageous accidents during the 51.