Histone lactylation promotes cell proliferation, migration and invasion through targeting HMGB1 in endometriosis.

Endometriosis is defined as a condition with endometrium-like tissues migrating outside of the pelvic cavity. However, the mechanism of endometriosis is still unclear. Lactate can be covalently modified to lysine residues of histones and other proteins, which is called lactylation.

Hierarchical microtubes constructed using Fe-doped MoS nanosheets for biosensing applications.

The structural design of multiple functional components could enhance the synergistic catalytic performance of MoS-based composites in enzyme-like catalysis. Herein, one-dimensional (1D) Fe-MoS microtubes were designed to prepare tubular Fe-doped MoS composites with MoO microrods as self-sacrificing precursors. Remarkably, the results indicated that the generated ammonia released from the sulfidation process led to the dissolution of MoO cores and the generation of a tubular structure.

Molecular subtypes, clinical significance, and tumor immune landscape of angiogenesis-related genes in ovarian cancer.

Angiogenesis is a physiological process, where new blood vessels are formed from pre-existing vessels through the mechanism called sprouting. It plays a significant role in supporting tumor growth and is expected to provide novel therapeutic ideas for treating tumors that are resistant to conventional therapies. We investigated the expression pattern of angiogenesis-related genes (ARGs) in ovarian cancer (OV) from public databases, in which the patients could be classified into two differential ARG clusters.

Construction of circRNA-associated ceRNA network reveals the regulation of fibroblast proliferation in cervical cancer.

Background: Cervical cancer is one of the major cancers that threaten the health of women. CircRNA is an important factor in the regulation of cancer development and progression. The role of circRNA in cervical cancer is less well studied.

A ratiometric fluorescent nanoprobe for ultrafast imaging of peroxynitrite in living cells.

For ratiometrically imaging peroxynitrite (ONOO) in living cells, we devised and fabricated a novel fluorescent nanoprobe, NC-NP, in this study. To achieve ratiometric fluorescence response towards ONOO, NC-NP used 3-(2-benzothiazolyl) coumarin (Cou-Bz) as the internal reference and 1,8-naphthimide derivative (Naph-PN) as a fluorescent ONOO probe. These compounds were incorporated into an amphiphilic block polymer called Pluronic F-127.

Coupled nickel-cobalt nanoparticles/N,P,S-co-doped carbon hybrid nanocages with high performance for catalysis and protein adsorption.

Carbon-supported bimetallic NiCo nanoparticles (NPs) have emerged as attractive catalysts and adsorbents for the reduction of 4-nitrophenol (4-NP) and separation of histidine-rich (His-rich) protein recently due to their low cost, high catalytic activity and good affinity for His-rich protein. In this study, new strongly coupled nickel-cobalt alloy/N,P,S co-doped carbon (NPSC) nanocages are rationally designed chemical etching of the ZIF-67 dodecahedron with Ni under sonication at room temperature, followed by poly(cyclotriphosphazene--4,4'-sulfonyldiphenol) (PZS) coating and subsequent carbonization treatment in a nitrogen atmosphere. When evaluated as a catalyst for 4-NP or an adsorbent for His-rich protein, the as-prepared NiCo@NPSC nanocages obtained at 700 °C show better performance than those obtained at other temperatures (500 and 900 °C).

Cyanidin-3--glucoside Regulates the Expression of in Brown Adipose Tissue by Activating Prdm16 Gene.

(1) Background: Brown adipose tissue (BAT) burns energy to produce heat. Cyanidin-3--glucoside (C3G) can then enhance the thermogenic ability of BAT in vivo. However, the mechanism by which C3G regulates Ucp1 protein expression remains unclear.

Simultaneous detection of dual biomarkers using hierarchical MoS nanostructuring and nano-signal amplification-based electrochemical aptasensor toward accurate diagnosis of prostate cancer.

Accurate and reliable quantification of tumor biomarkers in clinical samples is of vital importance for early stage diagnosis and treatment of cancer. However, a poor specificity of prostate specific antigen (PSA) testing alone fostering overdetection and overtreatment, remains a great controversy in prostate cancer (PCa) screening. Here we report an electrochemical aptasensor using hierarchical MoS nanostructuring and SiO nano-signal amplification for simultaneous detection of dual PCa biomarkers, PSA and sarcosine, to enhance the diagnostic performance of PCa.

Research progress on intervention effect and mechanism of protocatechuic acid on nonalcoholic fatty liver disease.

Nonalcoholic fatty liver disease (NAFLD) has become a surge burden worldwide due to its high prevalence, with complicated deterioration symptoms such as liver fibrosis and cancer. No effective drugs are available for NALFD so far. The rapid growth of clinical demand has prompted the treatment of NAFLD to become a research hotspot.

Construction of Bio-Nano Interfaces on Nanozymes for Bioanalysis.

Nanomaterials with enzyme-like activity (nanozymes) have been of great interest in broad applications ranging from biosensing to biomedical applications. Despite that much effort has been devoted to the development of the synthesis and applications of nanozymes, it is essential to understand the interactions between nanozymes and most commonly used biomolecules, i.e.

Pathogenic Heteroplasmic Somatic Mitochondrial DNA Mutation Confers Platinum-Resistance and Recurrence of High-Grade Serous Ovarian Cancer.

Purpose: Platinum resistance is a primary barrier to improving the survival rate of ovarian cancer. The relationship between mtDNA somatic mutations and response to platinum-based chemotherapy in ovarian cancer has not been well clarified.

Patients And Methods: Here, we employed the next-generation sequencing (NGS) platform to identify mtDNA mutations of the unrelated high-grade serous ovarian cancer (HGSOC) patients.

Malignant ascite-derived extracellular vesicles inhibit T cell activity by upregulating Siglec-10 expression.

To evade immune defense, cancer cells can employ extracellular vesicles (EVs) to inhibit the anti-tumor activity of lymphocytes in the tumor microenvironment. However, the mechanisms and key molecules that mediate the effects of EVs on lymphocytes are unclear. We used Quantibody Human Cytokine Antibody Array 440 to determine the tumor immunity-related cytokine profile of peripheral blood lymphocytes (PBLs) stimulated with EVs derived from peritoneal washes or malignant ascites.

Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high-risk HPV-positive women.

Background: Although high-risk human papillomavirus (HR-HPV) infection is recognized as the main cause of cervical cancer, only a minority of HPV-infected women develop this malignancy. Increasing evidence suggests that alterations of telomere length might be implicated in carcinogenesis. However, the association between cervical cancer and telomere length remains unknown.

miR-146a promotes cervical cancer cell viability via targeting IRAK1 and TRAF6.

Cervical cancer is the third most common type of cancer in women, and microRNAs play an important role in this type of cancer. The elevated expression of miR-146a is involved in the pathogenesis of cancers generally, but its role in cervical cancer has not been fully elucidated. In the present study, we assessed the expression of miR-146a in G>C polymorphisms and confirmed that the overexpression of miR-146a promoted cervical cancer cell viability.

Cytochrome P450 1A1 gene polymorphisms and cervical cancer risk: A systematic review and meta-analysis.

Objective: This meta-analysis aims to examine whether the MspI and Ile462Val polymorphisms of cytochrome P450 1A1 (CYP1A1) are associated with cervical cancer risk.

Methods: Eligible case-control studies were identified dated until July 2017. Pooled odds ratios (ORs) were used to assess the strength of the association between the two variants and cervical cancer risk.

Potential Significance of Peptidome in Human Ovarian Cancer for Patients With Ascites.

Objective: Ovarian cancer (OC) is one of the lethal gynecological malignancies. Most women affected by OC with malignant ascites will relapse. Peptidomics, as an emerging branch of proteomics, is more applied in screening of disease biomarkers, diagnosis, treatment, and monitoring.

Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway.

Protein Jumonji (JARID2), a member of the family of JmjC domain-containing proteins, has been reported to serve an important role in tumor growth and metastasis. However, the expression pattern and role of JARID2 in ovarian cancer remains unclear. Therefore, in the present study, the role of JARID2 in ovarian cancer was investigated, as well as the underlying mechanisms.

Comparative Gene Expression Analysis of Lymphocytes Treated with Exosomes Derived from Ovarian Cancer and Ovarian Cysts.

Cancer cells employ many strategies to evade immune defense and to facilitate tumor growth and angiogenesis. As a novel mode of intercellular communication, cancer-derived exosomes contribute to the recruitment and mediation of lymphocytes within the tumor environment. However, the mechanisms and key molecules mediating the effect of exosomes on lymphocytes are unclear.

All-trans retinoic acid suppresses topoisomerase IIα through the proteasomal pathway.

Topoisomerase IIα is a nuclear enzyme that alters DNA topology. It is a well-known anticancer target and related to cell differentiation status. All-trans retinoic acid (ATRA), an important active metabolite of vitamin A, is a promising anticancer agent in numerous malignancies.

Polymorphisms of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) and endometriosis risk: a meta-analysis.

Published data on the association between the glutathione S-transferases (GSTs) gene polymorphisms and endometriosis risk are inconclusive. We performed a meta-analysis to clarify the association of GSTM1 and GSTT1 polymorphisms and endometriosis risk. A comprehensive search was conducted to examine all the eligible studies of GSTM1 and GSTT1 polymorphisms and endometriosis risk.

Tumor necrosis factor α -308 G>A polymorphisms and cervical cancer risk: a meta-analysis.

Objective: Tumor necrosis factor α (TNF-α), secreted mainly by activated macrophages, is recently involved in fighting against tumorigenesis. Tumor necrosis factor α -308 G>A, the common polymorphism in the promoter of TNF-α, has been implicated to alter the risk of cervical cancer, yet the results of relative studies are inconclusive or controversial. To derive a more precise estimation of the relationship, we performed a meta-analysis based on 8 studies.

Polymorphism of the pre-miR-146a is associated with risk of cervical cancer in a Chinese population.

Objective: MicroRNAs are tiny non-coding RNAs that reportedly play an important role in numerous physiological processes. A G>C polymorphism (rs2910164) is located on the passenger strand of the precursor of miR-146a, which could alter mature miR-146a expression. We hypothesized that a possible association exists between miR-146a gene polymorphisms and cervical cancer risk in a population-based control study of female residents in Jiangsu Province.