Comparative study of diagnostic accuracy between office-based closed needle biopsy and open incisional biopsy in patients with musculoskeletal sarcomas.

Background: The biopsy is a simple but critical step in the diagnosis of the musculoskeletal lesions. Although the open incisional biopsy traditionally has been considered the gold standard with high diagnostic accuracy, an alternative, the closed needle biopsy (CNB), has been developed and widely used as it can be performed at an outpatient clinic under local anesthesia or in combination with the image guidance. In the present study, the authors purpose to study the diagnostic accuracy of CNB without real-time image-guidance at an outpatient clinic by comparing it with open incisional biopsy in musculoskeletal sarcoma patients.