Publications by authors named "Suphagan Boonpethkaew"
An equilibrium of skin microbiome is crucial for maintaining skin barrier function. However, external factors such as air pollution have the potential to disrupt this equilibrium. Hence, further investigation into the influence of air pollution on the skin microbiome emerges as a critical imperative.
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- - Psoriasis is a chronic skin condition where the growth of skin cells is more active than inflammation, particularly in the lesional center of the skin, and this growth is influenced by various growth factors (GFs).
- - The study analyzed skin samples from psoriasis patients to identify differentially expressed genes (DEGs) and found that specific growth factors (like EGF, FGF, PDGF, and HGF) are significantly involved in skin cell growth and inflammation.
- - The research suggests that these GFs may regulate gene expression related to both inflammation and growth in the affected skin areas, pointing toward potential new therapeutic targets for treating psoriasis.
Narrow band-ultraviolet B (NB-UVB) is an effective treatment for psoriasis. We aim to generate a potential mechanism of NB-UVB through comparing the transcriptomic profile before and after NB-UVB treatment between the peripheral edge of lesional skin (PE skin) and the center of lesional skin (CE skin) on the basis of molecular mechanisms of these two areas display different downstream functions. More than one-fourth of the NB-UVB-altered genes were found to be plaque-specific.
View Article and Find Full Text PDFBackground: Peripheral edge (PE) of plaques contains inflammatory molecules and has potential to initiate plaque formation, while the center (CE) of plaques has regression trends.
Objective: To elucidate the chronological molecular events by comparing the gene profiles in PE skin to those in CE skin.
Methods: Biopsied PE, CE, and uninvolved (UN) skin samples were analyzed by next-generation sequencing.
Elucidating transcriptome in the peripheral edge of the lesional (PE) skin could provide a better understanding of the molecules or signalings that intensify inflammation in the PE skin. Full-thickness biopsies of PE skin and uninvolved (UN) skin were obtained from psoriasis patients for RNA-seq. Several potential differentially expressed genes (DEGs) in the PE skin compared to those in the UN skin were identified.
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