Clinical efficacy of pioglitazone: generic vs. original product.

Background: Pioglitazone, an oral antidiabetic agent in the class of thiazolidinediones (TZDs), was widely used in the case of insulin tolerance as it provided more benefit to patients with type 2 diabetes. However, the original product is costly while some generic products are available at the substantial lower cost in Thailand. The objective of the present study was to assess bioequivalence in terms of efficacy between generic and original pioglitazone products.

Adverse effect of pioglitazone in military personnel and their families: a preliminary report.

Background: Thiazolidinediones (rosiglitazone and pioglitazone) whether administered alone or in combination with metformin, sulfonylurea, or insulin, are often accompanied by an increase in weight and/or plasma volume. Several studies have shown the adverse effect of weight gain and edema with rosiglitazone. But there was less data with pioglitazone, especially in military personnel and their families.