Intravitreal Ziv-Aflibercept versus Bevacizumab for Naïve Central Retinal Vein Occlusion with Macular Edema: An Interim Analysis of a Randomized Non-Inferiority Trial.

Purpose: To compare the efficacy of intravitreal ziv-aflibercept (IVZ) and bevacizumab (IVB) injections for the treatment of macular edema secondary to central retinal vein occlusion.

Methods: Participants were randomly assigned 1:1 to receive 3 monthly IVZ (1.25 mg/0.

Efficacy of Pars Plana Vitrectomy with Internal Limiting Membrane Peeling for Treatment of Large Idiopathic Full-Thickness Macular Holes.

Purpose: To evaluate anatomical and visual outcomes of pars plana vitrectomy (PPV) with internal limiting membrane peeling (ILMP) in large idiopathic full-thickness macular holes (FTMH). Predictive factors also formed part of the study.

Patients And Methods: A retrospective review of medical charts and optical coherence tomography images of patients with large idiopathic FTMH (≥400 µm) was conducted.

Comparative study of 1 DD and 2 DD radius conventional internal limiting membrane peeling in large idiopathic full-thickness macular holes: a randomized controlled trial.

Objective: To compare the surgical outcomes of 1-disc diameter (DD) and 2-DD conventional internal limiting membrane peeling (C-ILMP) in large full-thickness macular holes (FTMHs).

Materials And Methods: A prospective randomized controlled trial. One hundred patients with large idiopathic full-thickness macular hole (FTMH) were randomized into C-ILMP and extended C-ILMP (EC-ILMP) groups.

Oral Spironolactone versus Conservative Treatment for Non-Resolving Central Serous Chorioretinopathy in Real-Life Practice.

Objective: To compare the efficacy of oral spironolactone treatment versus conservative treatment for patients with persistent central serous chorioretinopathy (CSC) in real-life practice.

Design: Retrospective comparative study.

Patients And Methods: Medical records and retinal images of 62 patients with non-resolving CSC were reviewed.

Ocular angiostrongyliasis in Thailand: a retrospective analysis over two decades.

Purpose: To elucidate the clinical manifestations, management, and visual outcomes of patients with ocular angiostrongyliasis.

Methods: This was a single-center retrospective study of patients with ocular angiostrongyliasis presenting between 1995 and 2017 at Srinagarind Hospital, Khon Kaen, Thailand. Cases were found based on a search of diagnostic codes.

Laser-Induced Choroidal Neovascularizations: Clinical Study of 3 Cases.

Background: We report 3 patients with laser-induced choroidal neovascularization (CNV).

Method: Retrospective, observational case series. Medical charts and photographs were reviewed.

Systemic abnormalities associated with retinal vein occlusion in young patients.

Objectives: To study the systemic abnormalities associated with retinal vein occlusion in patients aged ≤50 years with a particular emphasis on atherosclerotic diseases and thrombophilic disorders.

Methods: Medical charts of patients, aged ≤50 years whose diagnoses were retinal vein occlusions during the period 1995-2015 were retrospectively reviewed. The primary outcome was the number of systemic abnormalities associated with these patients.

Spontaneous bilateral retinal pigment epithelium rips with good visual acuity.

Retinalpigment epithelium (RPE) rips commonly occur in retinochoroidal disorders including age-related macular degeneration, idiopathic polypoid alchoroidal vasculopathy, central serous chorioretinopathy, high myopia andchoroidal neovascularization. Most patients have unilateral involvement and poor visual prognosis. A 55-year-old female presented with decreased vision in her right eye for one week.

Advanced exudative retinopathy with neovascular glaucoma as the clinical presentation of diabetes mellitus and severe combined hyperlipidemia: a case report.

Unlabelled: A 50-year-old man presented with bilateralprogressive visual loss for 5 months. Visual acuity was reduced to countingfingers in the right eye and light perception in the left. Although neovascularizations were detected in the angles of the eyes, neovascular glaucoma and rubeosis iridis were demonstrated only in the left.

12-year retrospective study of Sturge-Weber syndrome and literature review.

Objective: To review the clinical manifestations and neuroimaging features of patients with Sturge-Weber syndrome (SWS) treated at Srinagarind Hospital over a 12-year period.

Material And Method: A retrospective study of sixteen patients with SWS (9 males and 7 females) was conducted. The medical records, photographs, and neuroimaging studies were reviewed

Results: All patients had port-wine stain (PWS) involving the eyelid.

Human papillomavirus genotypes and cervical cancer in northeast Thailand.

Human papillomavirus (HPV) is a major cause of cervical cancer. More than 100 HPV genotypes have been identified; however the distribution varies geographically and according to ethnicity. The purpose of this study was to investigate the prevalence and distribution of HPV subtypes among Northeast Thai women.

Hypoimmunoglobulinemia and protein C deficiency in a girl with Jacobsen syndrome: a case report.

Jacobsen syndrome is a rare contiguous gene syndrome caused by partial deletion of the long arm of chromosome 11. The typical clinical manifestations include physical growth retardation, mental retardation,facial dysmorphisms, congenital heart disease, thrombocytopenia, or pancytopenia. A Thai-Australian girl was born with multiple abnormalities.

Subretinal angiostrongyliasis-induced optic neuritis.

A 27-year-old Thai male presented with progressive visual loss and a membrane-like floater in the right eye that had persisted for 1 month. He had a history of eating raw foods, including snails. His initial visual acuity was counting fingers at 1 ft and he had a relative afferent pupillary defect.

Risk factors for cervical cancer in northeastern Thailand: detailed analyses of sexual and smoking behavior.

Cervical cancer is a serious public health problem in Thailand. We investigated possible risk factors for cervical cancer including HPV infection, p53 polymorphism, smoking and reproductive history among women in Northeast Thailand using a case control study with 177 cases and age-matched controls. Among the HPV carriers, a significantly increased risk for cervical cancer with an OR of 36.

Long versus short course treatment with metformin and clomiphene citrate for ovulation induction in women with PCOS.

Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive-aged women. Apart from infertility, women with PCOS often have other endocrine disorders, including insulin resistance, hyperinsulinaemia and hyperandrogenism. Metformin,combined with clomiphene citrate (CC), has been shown to be more effective in ovulation induction when compared with clomiphene citrate alone.

Migraine prophylaxis by anodal transcranial direct current stimulation, a randomized, placebo-controlled trial.

Background: Migraine is a common headache syndrome in adult populations. Prophylaxis is necessary to improve the quality of life but some patients with migraine have contraindication or suffer from side effects of medication, and therefore, establishing non-medical, neuromodulatory approaches is necessary. Past evidence had shown that consecutive motor cortex (M1) stimulation with anodal transcranial direct current stimulation (tDCS) was effective to relieve central pain.

Bilateral endogenous endophthalmitis in disseminated NTM infection: a case report.

A 47-year-old Thai female with underlying Sweet's syndrome and disseminated non-tuberculous mycobacterial infection presented with a history of blurred vision on both eyes after being lost to follow-up for eight months. The visual acuity was hand motion on the right eye and counting finger on the left eye. There was moderate inflammation in the anterior chamber and vitreous cavity.

Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial.

This study was undertaken to investigate the effects of green tea on weight reduction in obese Thais. A randomized, controlled trial involving 60 obese subjects (body mass index, BMI > 25 kg/m2) was conducted. All subjects consumed a Thai diet containing 3 meals (8373.

Potential applications of human embryonic stem cells.

Advances in reproductive technologies provided opportunity for scientists to be able to grow human embryos in vitro for more than two decades. Skills and knowledge derived from in vitro fertilization and in vitro culture of mammalian embryos opened the chance for scientists to develop the strategies to derive embryonic stem cell lines from mammalian and human embryos. This achievement has initiated a new era in the fields of biotechnology, pharmacology, basic scientific research, and cell-based medicine.

Tubal abnormalities in Thai infertile females.

Objective: To determine the prevalence of tubal abnormalities among infertile patients attending the clinic at Srinagarind Hospital.

Design: A descriptive study

Setting: Infertility clinic, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Thailand.

Subject: A total of 740 female patients presented at the infertility clinic, Srinagarind Hospital between 1 January 1998 and 31 December 2002.

Endometrial thickening in postmenopausal breast cancer patients taking tamoxifen: a cross-sectional study.

Objective: To determine the prevalence of endometrial thickening (endometrial thickness > 5 mm) in postmenopausal breast cancer patients taking tamoxifen.

Design: Cross-sectional descriptive study.

Settings: Srinagarind Hospital, Faculty of Medicine, Khon Kaen University.

Endometrial abnormalities in postmenopausal breast cancer patients.

Objective: To determine the prevalence of endometrial thickening and pelvic pathologies in postmenopausal breast cancer patients.

Material And Method: A total of 66 postmenopausal breast cancer patients receiving treatment at Srinagarind Hospital from 1 July 1999 to 31 August 2000 were included in the study. Patients who had been treated with hormones such as tamoxifen or progestins were not eligible for this study.

Increased risk of endometrial abnormalities in breast cancer patients taking tamoxifen: the need for gynaecologic surveillance.

Objective: To evaluate the risk of abnormally thickened endometrium associated with tamoxifen treatment in postmenopausal breast cancer patients.

Methods: Two groups of asymptomatic postmenopausal breast cancer patients were recruited in the study. The first consisted of 70 patients taking 20mg/day of tamoxifen for at least 6 months.

Surveillance for endometrial cancer in postmenopausal breast cancer patients taking tamoxifen.

Objectives: To determine the prevalence of endometrial thickening and endometrial pathologies in postmenopausal breast cancer patients taking tamoxifen.

Materials And Methods: A total of 37 postmenopausal breast cancer patients receiving 20 microg/day of tamoxifen treatment for at least 6 months at Srinagarind hospital were included in the study. Thorough history taking and physical examination as well as transvaginal ultrasonography were conducted for all patients.

Fetal abnormalities produced after preimplantation exposure of mouse embryos to ammonium chloride.

Background: The aims of this study were to determine whether preimplantation exposure of mouse embryos to ammonium resulted in abnormal fetal development and to evaluate similar risks to the outcome of human assisted conception.

Methods: Mouse embryos cultured from the 1-cell stage were exposed to 0.3 mmol/l ammonium chloride for 3 days.