Head-to-head comparison of F-FDG and F-FES PET/CT for initial staging of ER-positive breast cancer patients.

Purpose: To compare the diagnostic performance of F-fluorodeoxyglucose (F-FDG) and F-fluoroestradiol (F-FES) positron emission tomography/computed tomography (PET/CT) for initial staging of estrogen receptor (ER) positive breast cancer.

Methods: Twenty-eight patients with ER-positive breast cancer underwent F-FDG and F-FES PET/CT for initial staging. Diagnostic performance and concordance rates were analyzed for both radiotracers.