Publications by authors named "Supanee Nimsanor"

Objective: The aim of this study to determine the prevalence of CALR, MPL and c-kit gene mutations in JAK2 V617F negative-MPN patients.

Methods: The retrospective study of CALR, MPL and c-kit mutations were analyzed in 113 samples collected from March 2010 to May 2017 and identified as JAK2 V617F-negative MPN Thai patients. The samples were analysis by gel electrophoresis and direct sequencing.

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Article Synopsis
  • Vip3Aa protein, produced by Bacillus thuringiensis, is highly toxic to important insect pests like Spodoptera exigua and Spodoptera frugiperda, working by binding to specific midgut receptors and inducing cell death through apoptosis.
  • The protein is initially synthesized as a protoxin and requires activation by digestive enzymes to become effective, and its cytotoxic mechanism involves internalization into insect cells and disruption of cell division.
  • Research using fluorescent labeling of actVip3Aa revealed that the protein does not rely on clathrin-mediated endocytosis or target mitochondria, indicating a unique intracellular pathway leading to cytotoxicity.
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