The study aimed to review and analyze the effectiveness and safety of medications for treating acute urticaria, particularly in emergency and non-emergency settings.
Eight randomized clinical trials involving 680 patients were examined, finding that intramuscular first-generation H1-antihistamines reduced itching but caused more sedation, while intravenous second-generation H1-antihistamines showed better overall outcomes with fewer side effects.
The research concluded that H1-antihistamines are essential for treating acute urticaria, with intravenous second-generation H1-antihistamines being the preferred first-line treatment option due to their safety and effectiveness.