Topical combined Linn. and simvastatin improves wound healing in diabetic mice by enhancing angiogenesis and reducing neutrophil infiltration.

The present study aimed to investigate the effects of combined Linn. (PE) and simvastatin (SIM) on diabetic wounds in male BALB/C mice. Bilateral full thickness wound excisions were performed in the control and diabetic groups (45 mg/kg streptozotocin, intraperitoneally injected daily for 5 days).

The effects of oral on the efficacy of transplanted human endothelial cells and the expression of matrix metalloproteinases in diabetic wound healing.

Background: Diabetic wounds are characterized by delayed healing and impaired angiogenesis. and human umbilical vein endothelial cells (HUVECs) are reported to facilitate wound healing, and the former also has hypoglycemic property. Matrix metalloproteinases are enzymes that play a role in diabetic wound pathogenesis.

High dose oral vitamin C and mesenchymal stem cells aid wound healing in a diabetic mouse model.

Objective: This study sought to determine the effects of oral vitamin C (VitC) and mesenchymal stem cells (MSCs) on wound healing in diabetic nude mice.

Method: Bilateral, full-skin thickness wounds were created as an in vivo wound model in BALB/C diabetic nude mice. The mice were separated into five groups: control (CON); diabetes mellitus (DM, from a streptozotocin injection); DM treated with MSCs (DM+MSCs); DM treated with VitC (DM+VitC), and DM treated with MSCs and VitC (DM+MSCs+VitC).

Pleiotropic Effects of Simvastatin on Wound Healing in Diabetic Mice.

Objective: To evaluate the effects of pre-treatment with low-dose simvastatin on angiogenesis and wound healing in a diabetic mouse model.

Material And Methods: Balb/c nude mice were divided into three groups, including control (CON), diabetic (DM, and diabetic pre-treated with low-dose simvastatin (DM+ SIM). Seven days prior to wounding, the DM + SIM group was started on oral simvastatin (0.

Vasculoprotective effects of combined endothelial progenitor cells and mesenchymal stem cells in diabetic wound care: their potential role in decreasing wound-oxidative stress.

To investigate whether the combined endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs) could enhance angiogenesis and wound healing in diabetic mice. Balb/c nude mice were divided into five groups, including a control group, diabetic group (DM), DM injected with 1 × 10(6) cells MSCs, DM injected with 1 × 10(6) cells EPCs, and DM injected with combined 0.5 × 10(6) cells MSCs and 0.