Modulation of Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters.

Zinc (Zn) is the second most abundant metal in the human body and is essential for the function of 10% of all proteins. As metals cannot be synthesized or degraded, they must be assimilated from the diet by specialized transport proteins, which unfortunately also provide an entry route for the toxic metal pollutant cadmium (Cd). The intestinal absorption of Zn depends on the composition of food that is consumed, firstly the amount of Zn itself and then the quantity of other food constituents such as phytate, protein, and calcium (Ca).

Plant-Based Diet and Glycemic Control in Type 2 Diabetes: Evidence from a Thai Health-Promoting Hospital.

The prevalence of type 2 diabetes (T2DM) is associated with diet. While consumption of plant-based foods may reduce blood sugar levels, the impact of consuming plant-based foods on fasting blood sugar levels has not been well defined. This cross-sectional study was conducted at the Health-Promoting Hospital in Pak Phun Municipality, Thailand.

Predicting the work ability of security guards at a university in Nakhon Si Thammarat province, Thailand.

. The number of security guards in universities has increased significantly. This study aimed to predict work ability of university security guards.

Development and efficacy evaluation of a personalised self-care programme for reducing work-related musculoskeletal disorders among rubber farmers in Thailand.

Introduction: Work-related musculoskeletal disorders (WMSDs), the most common causes of work-related pain, suffering, absenteeism, and disability, are a major health concern for rubber farmers. WMSDs are persistent and frequently recur, resulting in increased health burdens for workers. Fortunately, appropriate intervention may relieve discomfort.

Soil heavy metal pollution from waste electrical and electronic equipment of repair and junk shops in southern Thailand and their ecological risk.

The waste electrical and electronic equipment (WEEE) stream in Thailand shifted from exporting WEEE to recycling them in domestic enterprises after China's import restrictions on e-waste in 2018. This study aims to investigate the pollution status, pollution sources, and ecological risk of heavy metals from manual WEEE dismantling facilities (12 repair shops and 8 junk shops) in the Nakhon Si Thammarat province of southern Thailand by examining the concentrations of As, Cd, Ni, and Pb in the topsoil (0-15 cm) during the wet and dry seasons. The results revealed that the mean concentrations of all heavy metals were higher during the dry season than in the wet season.

Estimation of the Cadmium Nephrotoxicity Threshold from Loss of Glomerular Filtration Rate and Albuminuria.

Cadmium (Cd) is a pervasive, toxic environmental pollutant that preferentially accumulates in the tubular epithelium of the kidney. Current evidence suggests that the cumulative burden of Cd here leads to the progressive loss of the glomerular filtration rate (GFR). In this study, we have quantified changes in estimated GFR (eGFR) and albumin excretion (E) according to the levels of blood Cd ([Cd]) and excretion of Cd (E) after adjustment for confounders.

Gender Differences in the Severity of Cadmium Nephropathy.

The excretion of β-microglobulin (βM) above 300 µg/g creatinine, termed tubulopathy, was regarded as the critical effect of chronic exposure to the metal pollutant cadmium (Cd). However, current evidence suggests that Cd may induce nephron atrophy, resulting in a reduction in the estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m.

Evidence Linking Cadmium Exposure and β-Microglobulin to Increased Risk of Hypertension in Diabetes Type 2.

The most common causes of chronic kidney disease, diabetes, and hypertension are significant public health issues worldwide. Exposure to the heavy metal pollutant, cadmium (Cd), which is particularly damaging to the kidney, has been associated with both risk factors. Increased levels of urinary β-microglobulin (βM) have been used to signify Cd-induced kidney damage and circulating levels have been linked to blood pressure control.

Chronic Kidney Disease Induced by Cadmium and Diabetes: A Quantitative Case-Control Study.

Kidney disease associated with chronic cadmium (Cd) exposure is primarily due to proximal tubule cell damage. This results in a sustained decline in glomerular filtration rate (GFR) and tubular proteinuria. Similarly, diabetic kidney disease (DKD) is marked by albuminuria and a declining GFR and both may eventually lead to kidney failure.

Cadmium-Induced Tubular Dysfunction in Type 2 Diabetes: A Population-Based Cross-Sectional Study.

The global prevalence of diabetes, and its major complication, diabetic nephropathy, have reached epidemic proportions. The toxic metal cadmium (Cd) also induces nephropathy, indicated by a sustained reduction in the estimated glomerular filtration rate (eGFR) and the excretion of β-microglobulin (βM) above 300 µg/day, which reflects kidney tubular dysfunction. However, little is known about the nephrotoxicity of Cd in the diabetic population.

Influence of climate variables on dengue fever occurrence in the southern region of Thailand.

The 3-5year epidemic cycle of dengue fever in Thailand makes it a major re-emerging public health problem resulting in being a burden in endemic areas. Although the Thai Ministry of Public Health adopted the WHO dengue control strategy, all dengue virus serotypes continue to circulate. Health officers and village health volunteers implement some intervention options but there is a need to ascertain most appropriate (or a combination of) interventions regarding the environment and contextual factors that may undermine the effectiveness of such interventions.

Health Risk in a Geographic Area of Thailand with Endemic Cadmium Contamination: Focus on Albuminuria.

An increased level of cadmium (Cd) in food crops, especially rice is concerning because rice is a staple food for over half of the world’s population. In some regions, rice contributes to more than 50% of the total Cd intake. Low environmental exposure to Cd has been linked to an increase in albumin excretion to 30 mg/g creatinine, termed albuminuria, and a progressive reduction in the estimated glomerular filtration rate (eGFR) to below 60 mL/min/1.

The construction and validation of a lead exposure screening tool for pregnant women in Thailand (ThaiL8Is).

Objectives: To construct, validate, and implement a new screening tool for lead exposure in Thai pregnant women.

Methods: A cross-sectional study that included three processes: screening tool development, validation, and implementation. The participants were pregnant women who had received antenatal care at district health promotion hospitals.

The NOAEL Equivalent of Environmental Cadmium Exposure Associated with GFR Reduction and Chronic Kidney Disease.

Cadmium (Cd) is a highly toxic metal pollutant present in virtually all food types. Health guidance values were established to safeguard against excessive dietary Cd exposure. The derivation of such health guidance figures has been shifted from the no-observed-adverse-effect level (NOAEL) to the lower 95% confidence bound of the benchmark dose (BMD), termed BMDL.

Blood Lead Levels among Non-Occupationally Exposed Pregnant Women in Southern Thailand.

Lead (Pb) is a heavy metal that is toxic to humans, especially children and pregnant women. In Thailand, guidelines exist to minimize lead exposure in pregnant women working in lead-related occupations. However, no guidelines exist for pregnant women who are not employed in these economic sectors.

Predictors of Low Back Pain Risk among Rubber Harvesters.

Low back pain (LBP) is a significant work-related musculoskeletal disorder among rubber farmers. This major occupational health problem was highly reported in the agricultural sector. While rubber farming is a profession with high risk of LBP, predictors for LBP remain unclear.

Effects of Environmental Exposure to Cadmium and Lead on the Risks of Diabetes and Kidney Dysfunction.

Environmental exposure to cadmium (Cd) or lead (Pb) is independently associated with increased risks of type 2 diabetes, and chronic kidney disease. The aim of this study was to examine the effects of concurrent exposure to these toxic metals on the risks of diabetes and kidney functional impairment. The Cd and Pb exposure levels among study subjects were low to moderate, evident from the means for blood concentrations of Cd and Pb ([Cd] and [Pb]) of 0.

Enhancing Toxicology Achievement by the VARK and the GRSLSS-mixed Models in Team-Based Learning.

Toxicology is needed to implement in the occupational health and safety (OHS) curriculum. Teaching toxicology is very challenging as its multidisciplinary science. Keeping students engaged in learning is a difficult issue when introducing solely theoretical framework.

Association between climate variables and dengue incidence in Nakhon Si Thammarat Province, Thailand.

The tropical climate of Thailand encourages very high mosquito densities in certain areas and is ideal for dengue transmission, especially in the southern region where the province Nakhon Si Thammarat is located. It has the longest dengue fever transmission duration that is affected by some important climate predictors, such as rainfall, number of rainy days, temperature and humidity. We aimed to explore the relationship between weather variables and dengue and to analyse transmission hotspots and coldspots at the district-level.

The Immunotoxicity of Chronic Exposure to High Levels of Lead: An Ex Vivo Investigation.

Lead (Pb) is a toxic metal known for its wide-ranging adverse health effects. However, a compound of Pb is still used in the caulking process to repair wooden fishing boats. The present study aimed to measure Pb exposure and its immunologic effects in boatyard workers in Nakhon Si Thammarat province, Thailand, in comparison with an age-matched control group of farmers.

Screening for Elevated Blood Lead Levels and Related Risk Factors among Thai Children Residing in a Fishing Community.

The present study explored environmental and behavioral factors associated with elevated blood lead (Pb) levels in 311 children (151 girls and 160 boys), aged 3-7 years, who lived in a coastal fishing community of the Pakpoon Municipality, Nakhon Si Thammarat, Thailand. The geometric mean for blood Pb was 2.81 µg/dL, ranging between 0.