Two main stream methods analysis and visual 3D genome architecture.

Multi-dimensions dynamics of the genome play important roles in the maintenance of cell function, regulation of transcriptional signals and occurrence of diseases. With rapid development of methodologies, the genome organization and structure are found as three-dimensional (3D) or with dynamic changes (4D), and regulated by a large number of factors. The present article aims to overview the 3C derivation method Hi-C and ChIA-PET assay technologies coupled with newdata analysis methods, capture the spatial interactions between different loci across the entire genome, reveal the regularity of the genome spatial structure.