Efficacy of vericiguat in patients with chronic heart failure and reduced ejection fraction: a prospective observational study.

Objectives: This study aims to evaluate the therapeutic effect of Vericiguat through cardiopulmonary exercise testing (CPET) in patients with chronic heart failure and reduced ejection fraction (HFrEF).

Methods: A prospective observational study was conducted from May 2022 to May 2023, focusing on patients with HFrEF admitted to our hospital. Eligible patients were sequentially numbered and enrolled based on specific inclusion and exclusion criteria.

An explainable and supervised machine learning model for prediction of red blood cell transfusion in patients during hip fracture surgery.

Aim: The study aimed to develop a predictive model with machine learning (ML) algorithm, to predict and manage the need for red blood cell (RBC) transfusion during hip fracture surgery.

Methods: Data of 2785 cases that underwent hip fracture surgery from April 2016 to May 2022 were collected, covering demographics, medical history and comorbidities, type of surgery and preoperative laboratory results. The primary outcome was the intraoperative RBC transfusion.

Bioinformatics and validation reveal the potential target of curcumin in the treatment of diabetic peripheral neuropathy.

Diabetic peripheral neuropathy (DPN) is a common nerve-damaging complication of diabetes mellitus. Effective treatments are needed to alleviate and reverse diabetes-associated damage to the peripheral nerves. Curcumin is an effective neuroprotectant that plays a protective role in DPN promoted by Schwann cells (SCs) lesions.

Tumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancer.

Background: Hematological metastasis has been recognized as a crucial factor contributing to the high rates of metastasis and mortality observed in colorectal cancer (CRC). Notably, exosomes derived from cancer cells participate in the formation of CRC pre-metastatic niches; however, the mechanisms underlying their effects are largely unknown. While our preliminary research revealed the role of exosome-derived disintegrin and metalloproteinase 17 (ADAM17) in the early stages of CRC metastasis, the role of exosomal ADAM17 in CRC hematogenous metastasis remains unclear.

Photocatalytic degradation of butyl benzyl phthalate by S-scheme Bi/BiOCO/BiS under simulated sunlight irradiation.

As a kind of plasticizer, butyl benzyl phthalate (BBP) presents a serious hazard to the ecosystem. Therefore, there is a strong need for an effective technique to eliminate the risk of BBP. In this work, a new photocatalyst of Bi/BiOCO/BiS with an S-scheme heterojunction was synthesized using Bi(NO) as the Bi source, NaS as the S source, and DMF as the carbon source and reductant.

Geochronological results from the Zhela Formation volcanics of the Tethyan Himalaya and their implications for the breakup of eastern Gondwana.

The relationship between the Kerguelen mantle plume and the breakup of eastern Gondwana is still debated. The new Zircon SHRIMP U-Pb dating of 139.9 ± 4.

Construction of Bi/BiOI/BiOCl Z-scheme photocatalyst with enhanced tetracycline removal under visible light.

Bi/BiOI/BiOCl composite photocatalyst was constructed by one-step stirring approach at ambient environment to remove of tetracycline (TC) antibiotics via photodegradation in aqueous medium. A systematic discussion of the architecture, composition, formation, photochemical performance and photocatalytic activity of Bi/BiOI/BiOCl was carried out. By adjusting the experimental conditions, it was found that the Bi/BiOI/BiOCl photocatalyst obtained by using 0.

Identification and validation of biomarkers related to Th1 cell infiltration in neuropathic pain.

Neuropathic pain (NP) is a widespread chronic pain with a prevalence of 6.9-10% in the general population, severely affecting patients' physical and mental health. Accumulating evidence indicated that the immune environment is an essential factor causing NP.

Photoelectrochemical biosensor for DNA demethylase detection based on enzymatically induced double-stranded DNA digestion by endonuclease-exonuclease system and BiOBr-Au/CdS photoactive material.

A novel photoelectrochemical (PEC) biosensor for the detection of DNA demethylase MBD2 was developed based on BiOBr-Au/CdS photosensitive material. BiOBr was firstly modified with gold nanoparticles (AuNPs), following with the modification onto the ITO electrode with CdS to realize the strong photocurrent response as a result of AuNPs had good conductibility and the matched energy between CdS and BiOBr. In the presence of MBD2, double-stranded DNA (dsDNA) on the electrode surface was demethylated, which triggered the digestion activity of endonuclease HpaII to cleave dsDNA and induced the further cleavage of the dsDNA fragment by exonuclease III (Exo III), causing the release of biotin labeled dsDNA and inhibiting the immobilization of streptavidin (SA) onto the electrode surface.

One-pot synthesis of 2D Ag/BiOCl/BiOCO S-scheme heterojunction with oxygen vacancy for photocatalytic disinfection of Fusarium graminearum in vitro and in vivo.

2D Ag/BiOCl/BiOCO S-scheme heterojunction was prepared with oxygen vacancy (OVs) via one-pot hydrothermal method. The XRD and XPS analysis indicated the synthesized sample contained Ag nanoparticles (AgNPs) instead of Ag ions. The SEM and HRTEM pictures showed that BiOCl/BiOCO nanosheets were modified with AgNPs.

One-pot solvothermal synthesis of Bi/BiS/BiWO S-scheme heterojunction with enhanced photoactivity towards antibiotic oxytetracycline degradation under visible light.

A novel noble-metal-free ternary Bi/BiS/BiWO S-scheme heterojunction and Schottky junction was successfully synthesized by one-pot solvothermal method. UV-Vis spectroscopy showed improved light absorption in the ternary composite structure. Electrochemical impedance spectroscopy and photoluminescence spectroscopy confirmed the reduced interfacial resistivity and photogenerated charge recombination rate of the composites.

RFC5, regulated by circ_0038985/miR-3614-5p, functions as an oncogene in the progression of colorectal cancer.

Replication factor C 5 (RFC5) is involved in a variety of biological functions of cancer. However, the expression pattern of RFC5 and the underlying mechanisms in colorectal cancer (CRC) remain elusive. Here, we show that RFC5 is significantly upregulated in CRC tissues and cells.

One-step synthesis of BiOCO/BiS S-scheme heterostructure with enhanced photoactivity towards dibutyl phthalate degradation under visible light.

BiOCO/BiS heterojunction was prepared by one-step hydrothermal method, where Bi(NO) was employed as Bi source, NaS was used as a sulfur source, and CO(NH) was adopted as C source. The load of BiS was adjusted by changing the content of NaS. The prepared BiOCO/BiS illustrated strong photocatalytic activity towards dibutyl phthalate (DBP) degradation.

Antibody-free photoelectrochemical strategy for simultaneous detection of methylated RNA, METTL3/METTL14 protein and MazF protein based on enhanced photoactivity of MoSe-BiOI nanocomposite.

Taking advantages of the catalytic activity of METTL3/METTL14 protein towards adenine methylation in RNA sequence and the specific digestion activity of MazF protein towards unmethylated RNA sequence containing ACA bases, a novel photoelectrochemical biosensor was constructed for simultaneous detection of RNA methylation, METTL3/METTL14 protein and MazF protein. MoSe-BiOI nanocomposite was prepared and considered as photoactive material, catalytic hairpin assembly strategy and in situ generation of electron donors catalyzed by polyaspartic acid-loaded alkaline phosphatase technique were employed as signal amplification. Under the optimum conditions, the detection ranges of methylated RNA, METTL3/METTL14 protein and MazF protein were 0.

Challenges of Large Vessel Vasculitis Stroke Patient with Complicated Endovascular Thrombectomy: A Case Report.

Purpose: The causes of acute stroke in patients with SLE are multifactorial. Antiphospholipid-associated hypercoagulability and inflammation-induced platelet activation are major causes of ischemic stroke in SLE patients. As such patients underwent intravenous thrombolysis and endovascular thrombectomy, they may have higher risk of complications and less favorable outcome.

STING promotes proliferation and induces drug resistance in colorectal cancer by regulating the AMPK-mTOR pathway.

Background: In recent years, reports regarding stimulator of interferon genes (STING) and the progression of colorectal cancer (CRC) have emerged rapidly, yet their association remains controversial. This research was aimed to provide an insight into the prognostic biomarker and therapeutic target significance of STING in CRC.

Methods: CRC Cell lines of HCT116 and SW480, as well as 32 paired CRC specimens were chosen for this study.

Controlled preparation of Bi/BiOCl with enhanced catalytic activity for organic pollutant under visible light using one-pot hydrothermal technology.

Flowerlike Bi/BiOCl was prepared by one-pot hydrothermal method, where Bi(NO) was used as Bi source, NiCl was used as employed as Cl source and co-catalyst, DMF was adopted as cosolvent and reducing agent. In the presence of NiCl, the reduction of Bi(NO) was accelerated. The prepared conditions were optimized.

Vortex radiation from a single emitter in a chiral plasmonic nanocavity.

Manipulating single emitter radiation is essential for quantum information science. Significant progress has been made in enhancing the radiation efficiency and directivity by coupling quantum emitters with microcavities and plasmonic antennas. However, there has been a great challenge to generate complex radiation patterns such as vortex beam from a single emitter.

Correction: A Novel Remote Follow-Up Tool Based on an Instant Messaging/Social Media App for the Management of Patients With Low Anterior Resection Syndrome: Pilot Prospective Self-Control Study.

[This corrects the article DOI: 10.2196/22647.].

A Novel Remote Follow-Up Tool Based on an Instant Messaging/Social Media App for the Management of Patients With Low Anterior Resection Syndrome: Pilot Prospective Self-Control Study.

Background: Low anterior resection syndrome (LARS) is a common functional disorder that develops after patients with rectal cancer undergo anal preservation surgery. Common approaches to assess the symptoms of patients with LARS are often complex and time-consuming. Instant messaging/social media has great application potential in LARS follow-up, but has been underdeveloped.

An efficient method for the synthesis of 2-pyridones C-H bond functionalization.

A simple and practical method to access N-substituted 2-pyridones via a formal [3+3] annulation of enaminones with acrylates based on RhIII-catalyzed C-H functionalization was developed. Control and deuterated experiments led to a plausible mechanism involving C-H bond cross-coupling and aminolysis cyclization. This strategy provides a short synthesis of structural motifs of N-substituted 2-pyridones.