Publications by authors named "Sunya Akhter"
Epigenetic dysregulation is a common mechanism shared by molecularly and clinically heterogenous neurodegenerative diseases (NDs). Histone acetylation homeostasis, maintained by the antagonistic activity of histone acetyltransferases (HATs) and histone deacetylases (HDACs), is necessary for appropriate gene expression and neuronal function. Disruption of neural acetylation homeostasis has been implicated in multiple types of NDs including Alzheimer's disease (AD), yet mechanisms underlying alterations remain unclear.
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- Disruption of the balance between Tip60 histone acetyltransferase (HAT) and histone deacetylase 2 (HDAC2) occurs early in the brain of Alzheimer's disease models, leading to cognitive decline before amyloid plaques develop.
- Repressing neuroplasticity genes is linked to increased HDAC2 binding, reduced Tip60 activity, and decreased histone acetylation, negatively impacting brain function.
- Restoring Tip60 levels in the brain has the potential to reverse these epigenetic changes, reactivate synaptic plasticity genes, and improve cognitive abilities.