Publications by authors named "Sunrae E Taloma"
The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits. In this work, we found that group 2 innate lymphoid cells (ILC2s) and their cytokine interleukin-13 (IL-13) signaled directly to inhibitory interneurons to increase inhibitory synapse density in the developing mouse brain.
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- * The study identifies a specific microglial state that responds to type I interferon (IFN-I) and actively engulfs neurons during the early postnatal development of the somatosensory cortex.
- * Alterations in IFN-I signaling impact microglial function, leading to neuronal damage and increased excitatory neurons, which may contribute to heightened sensitivity to touch, highlighting the importance of microglia in brain development and homeostasis.
The innate immune system plays essential roles in brain synaptic development, and immune dysregulation is implicated in neurodevelopmental diseases. Here we show that a subset of innate lymphocytes (group 2 innate lymphoid cells, ILC2s) is required for cortical inhibitory synapse maturation and adult social behavior. ILC2s expanded in the developing meninges and produced a surge of their canonical cytokine Interleukin-13 (IL-13) between postnatal days 5-15.
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- - Microglia, the brain's resident immune cells, play a crucial role in engulfing neurons during brain development, especially influenced by a distinct subset responsive to Type I interferon (IFN-I).
- - This specific microglial response was significantly increased after sensory deprivation in young mice, indicating their involvement in neural circuit remodeling.
- - Disrupting IFN-I signaling led to dysfunctional microglia and increased neuron stress, demonstrating IFN-I's essential role in maintaining proper neuronal health and development in the brain.
Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we define a molecular interaction between neurons and microglia that drives experience-dependent synapse remodeling in the hippocampus. We find that the cytokine interleukin-33 (IL-33) is expressed by adult hippocampal neurons in an experience-dependent manner and defines a neuronal subset primed for synaptic plasticity.
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