Publications by authors named "Sunny R K Singh"
Article Synopsis
- COVID-19 severely impacts cancer patients, particularly those with metastatic cancer, and this study explored the relationship between cancer metastasis and COVID-19 outcomes.
- Using data from the CCC19 registry, researchers analyzed over 10,000 cancer patients with COVID-19 to assess hospitalization rates and mortality based on the presence and site of metastasis.
- Findings showed that patients with metastases had higher hospitalization rates (59% vs. 49%) and 30-day mortality (18% vs. 9%), with those having lung metastases experiencing the highest risk of death in that timeframe.
Purpose: Prime childbearing years occur during medical training and early career, leaving physicians with tough choices between family planning and career growth. Restrictive workplace parental leave (PL) policies may negatively affect physician well-being. We evaluate existing PL and lactation policies, as well as return-to-work experiences, among oncology trainees and early-career faculty.
View Article and Find Full Text PDFImportance: Systematic data on the association between anticancer therapies and thromboembolic events (TEEs) in patients with COVID-19 are lacking.
Objective: To assess the association between anticancer therapy exposure within 3 months prior to COVID-19 and TEEs following COVID-19 diagnosis in patients with cancer.
Design, Setting, And Participants: This registry-based retrospective cohort study included patients who were hospitalized and had active cancer and laboratory-confirmed SARS-CoV-2 infection.
Introduction: COVID-19 particularly impacted patients with co-morbid conditions, including cancer. Patients with melanoma have not been specifically studied in large numbers. Here, we sought to identify factors that associated with COVID-19 severity among patients with melanoma, particularly assessing outcomes of patients on active targeted or immune therapy.
View Article and Find Full Text PDFBreakthrough SARS-CoV-2 infections among patients with cancer following two and three doses of COVID-19 mRNA vaccines: a retrospective observational study from the COVID-19 and Cancer Consortium.
Lancet Reg Health Am
March 2023
Article Synopsis
- Breakthrough SARS-CoV-2 infections post-vaccination are a major concern, particularly for cancer patients who are at higher risk of severe outcomes.
- A study analyzed 2,486 cancer patients with confirmed infections, focusing on the impact of receiving 2 or 3 doses of mRNA vaccines, looking at mortality and hospitalization rates.
- Results showed that vaccinated individuals had significantly lower 30-day mortality and hospitalization rates compared to unvaccinated patients, with those receiving 3 doses having the best outcomes.
Importance: Non-Hispanic Black individuals experience a higher burden of COVID-19 than the general population; hence, there is an urgent need to characterize the unique clinical course and outcomes of COVID-19 in Black patients with cancer.
Objective: To investigate racial disparities in severity of COVID-19 presentation, clinical complications, and outcomes between Black patients and non-Hispanic White patients with cancer and COVID-19.
Design, Setting, And Participants: This retrospective cohort study used data from the COVID-19 and Cancer Consortium registry from March 17, 2020, to November 18, 2020, to examine the clinical characteristics and outcomes of COVID-19 in Black patients with cancer.
Article Synopsis
- The COVID-19 pandemic has affected cancer patients differently across various regions in the U.S., showing that these patients are at a higher risk for severe COVID-19 complications.
- This study tracked and analyzed COVID-19 outcomes among cancer patients diagnosed between March and November 2020 across different U.S. census divisions, focusing on factors that may influence their health outcomes.
- Results indicated significant variability in 30-day mortality rates among cancer patients in different centers, ranging from 5.2% to 26.6%, suggesting that geographic location and healthcare center characteristics play a crucial role in these outcomes.
The incidence of invasive melanoma is rising, and approval for the first immune checkpoint inhibitor (ICI) to treat metastatic melanoma occurred in 2011. We aim to describe the epidemiology and outcomes in recent years, sociodemographic factors associated with the presence of metastasis at diagnosis, and the real-world impact of ICI approval on survival based on melanoma subtype and race. This is a retrospective analysis of the National Cancer Database (NCDB) from the years 2004-2015.
View Article and Find Full Text PDFBackground: Cardiopulmonary arrest is known to have a poor prognosis, further worsened by preexisting comorbidities. With improved treatment, the prevalence of metastatic cancers is rapidly increasing; however, the outcomes of in-hospital cardiopulmonary resuscitation (ICPR) remain to be well described. This study examines the epidemiology, associations, and outcomes of ICPR in these patients.
View Article and Find Full Text PDFWe describe a case of haemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis, which was treated with chemotherapy in addition to standard antifungal therapy. While HLH in the setting of infections is very well described, its treatment in this setting is controversial, with some physicians treating only the underlying infection, whereas others using immune suppression in addition to antimicrobials. To the best of our knowledge, this is the first report documenting the successful treatment of an adult patient with HLH due to disseminated histoplasmosis using etoposide chemotherapy after initial antifungal therapy failed to show improvement.
View Article and Find Full Text PDF(1) Background: Outcomes with coronavirus disease 2019 (COVID-19) have been worse in those with comorbidities and amongst minorities. In our study, we describe outcomes amongst cancer patients in Detroit, a major COVID-19 hotspot with a predominant inner-city population. (2) Methods: We retrospectively analyzed 85 patients with active invasive cancers who were infected with COVID-19.
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- Lung cancer screening (LCS) using low-dose CT scans significantly reduces lung cancer mortality, but it's not widely implemented, especially among providers treating underserved populations.
- An anonymous survey of Cook County Health primary care physicians revealed that while 72% had adequate knowledge of LCS, many failed to screen enough eligible patients, with only 57% ordering LCS in the past 6 months.
- Factors like higher patient volume and more experience correlated with better LCS implementation, and most respondents suggested that reminders in electronic medical records could help improve screening rates.
Article Synopsis
- Heparin-induced thrombocytopenia (HIT) is a rare immune reaction to heparin that leads to low platelet counts and can cause blood clots, with this study focusing on its impact in patients with solid tumors.
- Out of over 7 million hospitalizations for cancer, about 0.08% were diagnosed with HIT, showing that those with HIT had significantly higher rates of thrombotic events and mortality compared to those without HIT.
- The study concluded that while HIT is uncommon among cancer patients, it is linked to increased risks of complications and higher death rates, indicating a need for better management and awareness in this population.
Epidermal growth factor receptor (EGFR) mutation-driven lung cancer is a rare occurrence in patients with Li-Fraumeni syndrome (LFS) characterized by germline mutations in the tumor protein 53 (TP53) gene. Here we describe a case of primary EGFR mutation-driven lung adenocarcinoma in a young woman with LFS. There is only one other reported case with such presentation.
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