Publications by authors named "Sunlong Li"

Objectives: Oxidative stress, mitochondrial dysfunction, and apoptosis play significant roles in the degradation of extracellular matrix (ECM) in nucleus pulposus cells (NPCs), ultimately contributing to intervertebral disc degeneration (IVDD). This study investigates the potential of isoliquiritigenin (ISL), a natural extract known for its antioxidant, anti-inflammatory, and anti-atherosclerotic properties, to alleviate IVDD.

Methods: The viability of NPCs treated with ISL and tert-butyl hydroperoxide (TBHP) was assessed using the CCK-8 assay.

View Article and Find Full Text PDF
Article Synopsis
  • Soft-bodied aquatic organisms have inspired the creation of biomimetic actuators, which mimic their complex movements and adapt to liquid environments.
  • This study focuses on developing a water-based Janus adhesive hydrogel patch that responds to pH changes and can attach to specific areas of the gastrointestinal tract for targeted stimulation.
  • The innovative design incorporates unique microstructures and materials to achieve controlled movement and biofluid delivery, highlighting its potential for future medical applications in soft actuator technology.
View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on developing affordable and flexible pressure sensors for medical diagnostics, particularly in monitoring cervical health.
  • It addresses challenges in producing sensitive piezoresistive materials and proposes the use of hydrogel films that stick well to biological tissues for effective bio-signal monitoring.
  • The integration of a flexible pressure sensor with innovative hydrogel scaffolds shows potential to enhance sensor sensitivity and could significantly impact the manufacturing and functionality of cervical pressure sensors in personalized medicine.
View Article and Find Full Text PDF

Soft-bodied aquatic organisms have exhibited remarkable capabilities in navigating and moving within liquid environments serving as a profound inspiration for the development of bionic robots with intricate movements. Traditional rigid components are being replaced by stimulus-responsive soft materials such as hydrogels and shape memory polymers, leading to the creation of dynamically responsive soft robots. In this study, the development of a bionic robot inspired by the shape of an octopus and the adsorptive properties of its tentacles, specifically tailored for targeted stimulation and pH sensing in the cervix, are presented.

View Article and Find Full Text PDF
Article Synopsis
  • * Ferroptosis, a type of cell death linked to IVDD, can potentially be targeted for therapy; non-steroidal anti-inflammatory drugs (NSAIDs) like Tinoridine show promise in this area.
  • * The study reveals that Tinoridine binds strongly to Nrf2, a protein that helps inhibit ferroptosis, and that it can protect cells from ferroptosis in laboratory settings and improve IVDD symptoms in rat models.
View Article and Find Full Text PDF

In the quest to develop advanced monitoring systems for intestinal peristaltic stress, this study introduces a groundbreaking approach inspired by nature's sensory networks. By the integration of novel materials and innovative manufacturing techniques, a multifunctional Janus hydrogel patch has been engineered. This unique patch not only demonstrates superior stress-sensing capabilities in the intricate intestinal environment but also enables adhesion to wet tissue surfaces.

View Article and Find Full Text PDF

Study Design: A systematic review and meta-analysis.

Objective: This study aimed to evaluate the clinical efficacy of minimally invasive surgery (MIS) and open surgery in correcting ADS.

Summary Of Background Data: Adult degenerative scoliosis (ADS) is a scoliosis secondary to degenerative changes in the intervertebral discs and facet joints in adults.

View Article and Find Full Text PDF

In vivo surgical interventions require effective management of biofluids, including controlling bleeding and removing excess biofluids such as bile, wound exudate, and blood. To address these issues, recent advances have emerged, such as self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist.

View Article and Find Full Text PDF

Increasing attention has been paid recently to superwettability and its prospective potential applications in various fields. A new approach towards the establishment of flexible, self-assembled superhydrophobic surfaces with self-reported wettability on a variety of substrates has been advanced. The approach involves the fabrication of a dense monolayer of photonic crystal films that possess a layered structure with superior adhesion at the liquid-gas-solid interface.

View Article and Find Full Text PDF

Effects of Orientin on murine chondrocytes treated with interleukin-1β (IL-1β) were evaluated using qPCR, western blot analysis, ELISA, and immunofluorescent staining in vitro. In vivo, We established a standard OA model by performing the destabilized medial meniscus (DMM) surgery on C57BL/6 mice, and assessed healing effect of Orientin by X-ray imaging, histopathological analysis, immunohistochemical staining. Osteoarthritis (OA) is the most common form of degenerative joint disease in clinic and the chondrocyte inflammation plays the most important role in OA development.

View Article and Find Full Text PDF

Osteoarthritis (OA) is a common joint illness that negatively impacts people's lives. The main active ingredient of cassia seed or rhubarb is chrysophanol. It has various pharmacological effects including anticancer, anti-diabetes and blood lipid regulation.

View Article and Find Full Text PDF

Intervertebral disc degeneration (IVDD) is a major cause of low back pain. Diabetes mellitus is a chronic inflammatory disease that may cause or aggravate IVDD; however, the mechanism by which diabetes induce IVDD is currently unclear. Compared to non-diabetic individuals, diabetic patients have higher levels of plasma cytokines, especially TNF-α, IL-1β, IL-5, IL-6, IL-7, IL-10, and IL-18.

View Article and Find Full Text PDF

Electronic skins have attracted significant research interest in the biomedical engineering field including wearable devices, artificial prostheses, software robots, and so on. However, the integration of electronic skin for use in rehabilitation exercise remains unexplored. Here, we propose a novel, conductive structurally colored composite hydrogel for use as a robotic knuckle rehabilitation skin.

View Article and Find Full Text PDF

Mitochondrial dynamics, including mitochondrial fission and fusion, are critical for maintaining mitochondrial functions. Evidence shows that TANK-binding kinase 1 (TBK1) regulates mitochondrial fusion and fission and then mitophagy. Since a previous study demonstrates a strong correlation between mitophagy and osteoarthritis (OA), we herein investigated the potential role of TBK1 in OA process and mitochondrial functions.

View Article and Find Full Text PDF
Article Synopsis
  • OA is a joint disease largely characterized by inflammation, and Corynoline (COR) shows potential anti-inflammatory effects that may aid in its treatment.
  • Research methods included assessing cell viability, examining inflammation markers, and using various imaging techniques to test COR's impacts on OA in models.
  • Results indicate that COR protects against ECM degeneration and inflammation by interacting with the Nrf2/NF-κB pathway, suggesting its therapeutic potential for managing OA.*
View Article and Find Full Text PDF

Background: Osteoarthritis (OA) is a globally prevalent degenerative disease characterized by extracellular matrix (ECM) degradation and inflammation. Tangeretin is a natural flavonoid that has anti-inflammatory properties. Studies have not explored whether tangeretin modulates OA development.

View Article and Find Full Text PDF

Osteoarthritis (OA) is presently the most prevalent form of chronic degenerative joint disease, which is characterized by erosion of articular cartilage, subchondral bone sclerosis and synovitis. Accumulating evidence has revealed that 18β-glycyrrhetinic acid (18β-GA), a major bioactive component derived from , exerts anti-inflammatory effects on several diseases. However, the anti-inflammatory effects of 18β-GA on OA remain undetermined.

View Article and Find Full Text PDF

Inflammation and extracellular matrix (ECM) degradation have been implicated in the pathological process of osteoarthritis (OA). α-Cyperone is the main active component of the traditional Chinese medicine . In this study, we found that α-Cyperone abolished the IL-1β-induced production of inflammatory cytokines in isolated rat chondrocytes, such as cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS), in a dose-dependent manner (0.

View Article and Find Full Text PDF

Intervertebral disc degeneration (IVDD) has been reported to be a major cause of low back pain. Studies have demonstrated that IVDD may be dysregulated at the transcriptional level; however, whether post-transcriptional regulation is involved is still unknown. The current study aimed to illustrate the role of Human antigen R (HuR), an RNA binding protein involved in post-transcriptional regulation, in IVDD.

View Article and Find Full Text PDF
Article Synopsis
  • Endothelial progenitor cells (EPCs) are important for tissue repair and were tested for their ability to enhance flap survival in a rabbit model.* -
  • In the study, rabbits were split into three groups: sham, control, and EPC transplantation; flap survival and blood flow were assessed post-surgery.* -
  • Results showed that the EPC group had a significantly higher flap survival rate (58.4%) compared to the control group (4.8%), along with improved microvessel density and elevated levels of eNOs and VEGF.*
View Article and Find Full Text PDF

Purpose: Intraosseous ganglion cyst (IGC) is a rare disease, particularly in lunate. The objective of this study was to summarize current knowledge on the treatment of IGC of the lunate, through a literature review, to provide a therapeutic strategy for this rare disease.

Methods: The PubMed, ISI Web of Science, Cochrane Library, EMBASE, Science Direct database were searched with a set of predefined inclusion and exclusion criteria.

View Article and Find Full Text PDF