COVID-19 Serostatus Does Not Affect the Intrauterine Transfer of Micronutrients and Fatty Acids or Maternal-fetal Lymphocyte Cell Composition: An Observational Study.

Objective:  Studies on the effects of coronavirus disease 2019 (COVID-19) on pregnant mothers and their newborns, specifically in relation to their micronutrient status, fatty acids (FAs), and inflammatory status are sparse. We hypothesized that COVID-19 infection would adversely affect the transfer of nutrients, and FAs from mothers to their fetuses via the umbilical cord and maternal-fetal distribution of inflammatory cells. This study aimed to determine the effect of COVID-19 on micronutrients, inflammatory markers, and FAs profiles in pregnant mothers and their newborns' cord blood.

Survival Probability in Multidrug Resistant Pulmonary Tuberculosis Patients in a South Indian Region.

Drug-resistant tuberculosis is a burgeoning threat to public health requiring novel strategies to combat the infection. Although national tuberculosis elimination programs focus on improving health services, challenges in eradicating tuberculosis still exist. Factors attributing to unfavorable outcomes are unknown in Warangal district of Telangana state.

Compact MIMO UWB antenna integration with Ku band for advanced wireless communication applications.

This paper introduces a compact Multiple Input Multiple Output (MIMO) Ultrawideband (UWB) antenna seamlessly integrated with the Ku band, tailored for wireless communication applications. The MIMO antenna employs octagonal radiators, crafted from a tapered microstrip line-fed rectangular patch, etched on an economically efficient FR4 substrate measuring 40 × 23 mm. The octagonal configuration is achieved by introducing a rectangular patch to the central radiator, while parasitic stubs are strategically employed to mitigate coupling among MIMO elements.

Interaction analysis of SARS-CoV-2 omicron BA1 and BA2 of RBD with fifty monoclonal antibodies: Molecular dynamics approach.

This report provides detailed insights into the interaction of fifty monoclonal antibodies with two recent Omicron variants, BA1 and BA2. It has been observed that numerous mutations in the receptor binding domain (RBD) result in significant structural changes in Omicron, enhancing its ability to mediate viral infections compared to other variants of concern. The following antibodies, namely JX3S304, 7KMG, 7CH4, 7BELCOVOX45, 7CDJ, 7C01, 7JX3S2H14, 6XCA, 7CDI, 7JMO, 7B3O, 6ZER, 6XC7CR3022, JX3S309, 6XC7CC123, 7CM4, 7KMI, 7L7EAZD8895, exhibit a superior binding affinity towards the Spike when compared to the reference CR3022.

Design and Analysis of Modified U-Shaped Four Element MIMO Antenna for Dual-Band 5G Millimeter Wave Applications.

A novel compact-slotted four element multiple input multiple output (MIMO) planar monopole antenna is proposed for 5G mmWave N257/N258 and N262 band applications. The antenna, with dimensions of 12 mm × 11.6 mm × 0.

A fully labelled image dataset of banana leaves deficient in nutrients.

Agriculture is the art and science of cultivating the soil, growing crops and raising livestock. Enhancing crop yield becomes essential to improve economy in agriculture sector. Crops need 16 essential nutrients in balanced factor for their proper growth.

Antidiabetic activity of fruit extract in streptozotocin-induced diabetic rats.

Background: Swartz, a medicinal plant belonging to the family Solanaceae, is an important medicinal plant widely distributed throughout the world and used as medicine to treat diabetes, hypertension, tooth decay, and reproductive problems in traditional systems of medicine around the world including Malaysia. The objective of this study was to investigate hypoglycemic, antilipidemic, and hepatoprotective activities, histopathology of the pancreas, and specific glucose regulating gene expression of the ethanolic extract of fruit in streptozotocin-induced diabetic Sprague-Dawley rats.

Materials And Methods: Acute toxicity study was done according to OECD-423 guidelines.

HES1 promoter activation dynamics reveal the plasticity, stemness and heterogeneity in neuroblastoma cancer stem cells.

Notch signaling and its downstream gene target HES1 play a critical role in regulating and maintaining cancer stem cells (CSCs), similar to as they do during embryonic development. Here, we report a unique subclass of Notch-independent Hes-1 (NIHes-1)-expressing CSCs in neuroblastoma. These CSCs maintain sustained HES1 expression by activation of HES1 promoter region upstream of classical CBF-1 binding sites, thereby completely bypassing Notch receptor-mediated activation.

Metabolite Effect on Angiogenesis: Insights from Transcriptome Analysis.

Metabolic status of the cells is important in the expression of the angiogenic phenotype in endothelial cells. Our earlier studies demonstrated the effects of metabolites such as lactate, citrate and lipoxygenase products, on VEGFA-VEGFR2 signaling pathway. Though this link between metabolite status and molecular mechanisms of angiogenesis is becoming evident, it is not clear how it affects genome-level expression in endothelial cells, critical to angiogenesis.

Temporal VEGFA responsive genes in HUVECs: Gene signatures and potential ligands/receptors fine-tuning angiogenesis.

Vascular Endothelial Growth Factor-A (VEGFA) signaling is crucial to the cellular processes involved in angiogenesis. Previously, we assembled a network of molecular reactions induced by VEGFA in human umbilical vein endothelial cell populations. Considering transcriptome as a read-out of the transcriptional and epigenomic regulatory network, we now present an analysis of VEGFA-induced temporal transcriptome datasets from 6 non-synchronized studies.

Reparation of Isoniazid and Rifampicin Combinatorial Therapy-Induced Hepatotoxic Effects by Bacopa monnieri.

Drug-induced liver injury is a major challenge in treating tuberculosis with isoniazid (INH) and rifampicin (RIF). This study was aimed at evaluating the protective effects of Bacopamonnieri (Brahmi) against INH and RIF-induced hepatotoxicity in a rat model and also to study the patterns of interaction between pregnane X receptor (PXR) and chosen active compounds of B. monnieri.

Agenesis of isthmus of thyroid gland, its embryological basis and clinical significance--a case report.

A wide range of morphological varieties and developmental anomalies of the thyroid gland have been reported in literature such as hypoplasia, ectopy, hemi agenesis, and agenesis. Out of these the incidence of agenesis of the isthmus of thyroid gland is rare and very few cases have been reported. In the present case report a male cadaver was found with agenesis of isthmus of thyroid gland with pyramidal lobe and levator glandulae thyroidae arising from right lobe.

Isolated intracranial Rosai-Dorfman disease mimicking meningioma in a child: a case report and review of the literature.

We report the first case of extensive involvement of isolated intracranial Rosai-Dorfman's disease (RDD) in a child. Our case is unique because it presents with involvement of the middle cranial fossa, cavernous sinus, pituitary gland, orbit, ethmoid and sphenoid sinuses. Previous cases of intracranial RDD in children have reported separate involvement of cavernous sinus, suprasellar region, and frontal and petroclival regions.

A supratentorial primary parenchymal paraganglioma.

Primary intracerebral paraganglioma is an unusual entity in the diagnostic armamentarium of the neurosurgeon. Only two patients have been described with a supratentorial intra-parenchymal subtype. We report a 40-year-old man who presented with features of raised intracranial pressure and secondary visual deterioration of short duration.

Left ectopic kidney with non rotation: a case report.

Congenital anomalies of the urinary tract system are common. The ectopic pelvic kidney is a rare anomaly about 1:2500 live births, left side being more common. Here we are reporting a case of left ectopic kidney with non rotation and morphologically normal right kidney.

Rare variations in the formation of median nerve--embryological basis and clinical significance.

During routine dissection in the Department of Anatomy, CMS, Nepal, anomalous median nerves with regard to their formation were found in three different adult male cadavers. In one cadaver, there was variation in the formation of the median nerve and its relation with the axillary artery. Another cadaver revealed the formation of the median nerve by three roots, while in the third one, the median nerve was found to be formed by four roots.

Variation in relation of cords of brachial plexus and their branches with axillary and brachial arteries--a case report.

Anatomical variations in the formation, course and distribution of brachial plexus are well documented. The present report describes some rare variations with regard to relation of cords of brachial plexus, median and ulnar nerves with the third part of axillary artery and brachial artery in the left upper limb of an adult male cadaver. All three cords of brachial plexus were noted to be lateral to all three parts of axillary artery.