Infection-related mortality in children with acute lymphoblastic leukemia: an analysis of infectious deaths on UKALL2003.

Although infection is the major cause of treatment-related mortality (TRM) in childhood acute lymphoblastic leukemia, factors associated with infection-related mortality (IRM) are poorly understood. To address this, we report an analysis of all 75 cases of IRM in the United Kingdom Childhood Acute Lymphoblastic Leukaemia Randomised Trial 2003 (UKALL 2003). The 5-year cumulative incidence of IRM was 2.

Measurement, causes and management of overweight and obesity in children.

Childhood obesity is a growing problem that has serious implications for future generations. The cause is multifactorial, with contributions from genetics and the environment. Management needs to be targeted at the population as a whole, with improved education and strategies to improve lifestyle and behaviour.