Publications by authors named "Sunit K Sahoo"
Article Synopsis
- A topical microemulsion-based hydrogel (HLM) was created to improve the delivery of the antifungal drug liranaftate (LRFE) for treating skin fungal infections.
- The formulation involved components like Di-isopropyl adaptate and Xanthan Gum, with results showing that HLM-3 had a higher permeation rate and drug deposition in skin compared to saturated drug solutions.
- Testing indicated that HLM-3 demonstrated superior antifungal activity with a larger zone of inhibition against Candida albicans, and it was well-tolerated without causing skin irritation.
The objectives of the present research project were to formulate, evaluate and perform antimicrobial study and drug delivery behavior of nanocomposite material based on biopolymer chitosan and organically modified montmorillonite clay; i.e. cloisite 10A.
View Article and Find Full Text PDFThis study aims to develop a self-nanoemulsifying drug delivery system (SNEDDS) based on non-ionic surfactant mixtures to improve the oral bioavailability of efavirenz (EFZ) categorized as a class II according to the BCS, for HIV- therapy. The result of solubility studies of EFZ in various excipients utilized for construction of the pseudo ternary phase diagram containing surfactant mixtures. Surfactants in 1:1 combination are used with different co-surfactants in different ratio to delineate the area of monophasic region of the pseudo ternary phase diagram.
View Article and Find Full Text PDFMicroemulsion based topical hydrogel of sertaconazole: formulation, characterization and evaluation.
Colloids Surf B Biointerfaces
August 2014
A microemulsion (ME) based hydrogel had studied as a topical delivery of sertaconazole (STZL) for effective eradication of cutaneous fungal infection. The existence of microemulsion region was investigated in pseudo-ternary phase diagrams and various ME formulations were prepared using oleic acid, Tween 80, propylene glycol and water. Hydrogel of STZL microemulsions (HSM) were prepared in Carbopol 940 (0.
View Article and Find Full Text PDFPurpose: A topical microemulsion (ME)-based hydrogel was developed to enhance permeation of an antifungal drug, sertaconazole (STZL) for effective eradication of cutaneous fungal infection.
Methods: Pseudo-ternary phase diagrams were used to determine the existence of MEs region. ME formulations were prepared with oleic acid, Tween 80, propylene glycol (PG) and water.