Publications by authors named "Sunint Bindra"
Polymicrobial infections of the gastro-intestinal tract are common in areas with poor sanitation. Disease outcome is the result of complex interactions between the host and pathogens. Such interactions lie at the core of future management strategies of enteric diseases.
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- The study examines the relationship between genetics and the disease phenotype of Crohn's disease (CD) and ulcerative colitis (UC) in a Canadian cohort, focusing on genetic risk scores (GRS) based on identified IBD-risk loci.
- It finds that higher GRS correlates with earlier onset and more severe forms of CD but not with UC, where genetic burden did not predict diagnosis age, disease extent, or treatment needs.
- The research suggests that understanding genetic contributions may enhance predictions of disease behavior in CD, although this connection remains unclear for UC.