Adverse reactions associated with SSRIs and PD-1/PD-L1 inhibitors: a disproportionality analysis of the FDA Adverse Event Reporting System.

Background: Selective serotonin reuptake inhibitors (SSRIs) are the primary choice for antidepressant therapy in cancer patients with depression. Programmed death-1 and programmed cell death-ligand 1 (PD-1/PD-L1) play a critical role in immune checkpoint inhibitors. To date, there have been no studies reporting adverse events (AEs) associated with the real-world use of PD-1/PD-L1 inhibitors-SSRIs combination.

Evaluation of dust fixation effect of urease-based biological dust suppressant and its field application.

Widespread mining of open-pit coal mines has led to severe dust pollution, which degrades air quality and affects human health. Due to the drawbacks of existing dust suppression methods, there is an urgent need to develop a biological dust suppressant, which is based on urease-induced carbonate precipitation and has excellent potential for application in the field of dust management. The research developed a biological dust suppressant based on urease-induced carbonate precipitation technology.

Effectiveness and mechanism of microbial dust suppressant on coal dust with different metamorphosis degree.

The extraction of coal from open-pit mines significantly contributes to environmental degradation, posing grave risks to human health and the operational stability of machinery. In this milieu, microbial dust suppressants leveraging microbially induced carbonate precipitation (MICP) demonstrate substantial potential for application. This manuscript undertakes an exploration of the dust mitigation efficiency, consolidation attributes, and the fundamental mechanisms of microbial dust suppressants across coal dust samples with varying metamorphic gradations.

Nitrogen inhibition of nitrogenase activity involves the modulation of cytosolic invertase in soybean nodule.

Legume symbiotic nitrogen fixation (SNF) is suppressed by inorganic nitrogen (N) in the soil. High N inhibition of nitrogenase activity is associated with the deprivation of carbon allocation and metabolism in nodules. However, the underlying molecular mechanisms remain unclear.

High-efficiency broadband achromatic metalenses for visible full-stokes polarization imaging.

Polarization-imaging technology has important applications in target detection, communication, biomedicine, and other fields. A polarization imaging system based on metalenses, which provides new possibilities for the realization of highly integrated full-Stokes polarization imaging systems, can solve the problems of traditional polarization imaging systems, such as complex structures, large volumes, and the inability to simultaneously obtain linear and circular polarization states. However, currently designed metalens arrays that can achieve real-time full-Stokes polarization imaging can generally only be used for monochromatic detection, which significantly limits the amount of measured information of the object.

SCN-MLTPP: A Multi-Label Classifier for Predicting Therapeutic Properties of Peptides Using the Stacked Capsule Network.

Identifying the function of therapeutic peptides is an important issue in the development of novel drugs. To reduce the time and labor costs required to identify therapeutic peptides, computational methods are increasingly required. However, most of the existing peptide therapeutic function prediction models are used for predicting a single therapeutic function, ignoring the fact that a bioactive peptide might simultaneously consist of multi-activities.

[Research Status of and Recommendations for Prevention and Control of Sleep Disorders in China].

The quality of sleep, a key physiological factor that regulates information, memory, decision making, and other vital brain functions, can affect important physiological functions of the human body. According to disease classification systems, sleep disorders can be categorized into more than 90 types, including sleep apnea, insomnia, and hypersomnia. It may cause a variety of adverse consequences, such as depression, anxiety and other emotional disorders, as well as physical diseases such as hypertension, diabetes and stroke.

Self-Healing Coating with a Controllable Release of Corrosion Inhibitors by Using Multifunctional Zinc Oxide Quantum Dots as Valves.

As an intelligent response system, self-healing anticorrosion materials containing nanocontainers have aroused increasing demands. It is highly expected that the nanocontainers can rapidly respond on corrosion signals to efficiently release corrosion inhibitors, meanwhile to avoid an undesirable leakage before the local corrosion happening. Herein, zinc oxide quantum dot (ZnO-QD)-sealed hollow mesoporous TiO nanocontainers loading with 14.

The prevalence of hypertension in Chinese adolescents aged 15-17 years: A comparison of different criteria.

This study intended to compare the prevalence of hypertension in adolescents aged 15-17 years in China according to different criteria defined by various guidelines. We included 28 715 adolescents aged 15-17 years from the China Hypertension Survey study (CHS) 2012-2015, and the 2017 American Association of Pediatrics (AAP) Clinical Practice Guideline and 2018 Chinese guidelines for children and adults were used to define hypertension. The prevalence of hypertension among Chinese adolescents aged 15-17 years was 24.

Hypertension-mediated organ damage and established cardiovascular disease in patients with hypertension: the China Hypertension Survey, 2012-2015.

Hypertension is a major health burden worldwide. However, there is limited data on the status of hypertension-mediated organ damage (HMOD) and established cardiovascular (CV) disease in Chinese hypertensive patients. The aim of this study is to determine the prevalence of HMOD and established CV disease in a nationally representative population in China.

Current status and etiology of valvular heart disease in China: a population-based survey.

Background: The epidemiology of valvular heart disease (VHD) has changed markedly over the last 50 years worldwide, and the prevalence and features of VHD in China are unknown. The objective of this study was to investigate the current status and etiology of VHD in China.

Methods: We used a cross-sectional national survey with stratified multistage random sampling from the general Chinese population to estimate the VHD burden.

A survey on predicting microbe-disease associations: biological data and computational methods.

Various microbes have proved to be closely related to the pathogenesis of human diseases. While many computational methods for predicting human microbe-disease associations (MDAs) have been developed, few systematic reviews on these methods have been reported. In this study, we provide a comprehensive overview of the existing methods.

Drug-drug similarity measure and its applications.

Drug similarities play an important role in modern biology and medicine, as they help scientists gain deep insights into drugs' therapeutic mechanisms and conduct wet labs that may significantly improve the efficiency of drug research and development. Nowadays, a number of drug-related databases have been constructed, with which many methods have been developed for computing similarities between drugs for studying associations between drugs, human diseases, proteins (drug targets) and more. In this review, firstly, we briefly introduce the publicly available drug-related databases.

1,25(OH)D provides protection against diabetic kidney disease by downregulating the TLR4-MyD88-NF-κB pathway.

The over-activation of Toll-like receptors (TLRs) is a typical immune response to injury. Previous work has suggested that controlling the over-activation of TLR4-MyD88-NF-κB may represent a new therapeutic option for diabetic kidney disease (DKD). 1,25(OH)D has also been shown to exert a protective effect on DKD, although the mechanism involved has yet to be elucidated.

Prevalence of overweight and obesity in China: Results from a cross-sectional study of 441 thousand adults, 2012-2015.

Objectives: Obesity has become a global health public problem. The study aims to examine the latest prevalence of overweight and obesity in China.

Methods: Data came from the China Hypertension Survey (CHS), a nationally representative cross-sectional study among residents aged ≥18 years from October 2012 to December 2015.

Effect of a Workplace-Based Multicomponent Intervention on Hypertension Control: A Randomized Clinical Trial.

Importance: A workplace-based intervention could be an effective approach to managing high blood pressure (BP). However, few studies to date have addressed hypertension control among the Chinese working population.

Objective: To assess the effect of a workplace-based, multicomponent intervention strategy on improving BP control.

Prevalence of Abdominal Obesity in China: Results from a Cross-Sectional Study of Nearly Half a Million Participants.

Objective: This study aimed to examine the latest prevalence of abdominal obesity in China based on nationally representative data.

Methods: A stratified, multistage, random sampling method was used to obtain a nationally representative sample of residents aged ≥ 18 years from 31 provinces in mainland China from October 2012 to December 2015. Abdominal obesity was defined as a waist circumference ≥ 90 cm for men and a waist circumference ≥ 85 cm for women.

High-Accuracy Correction of a Microlens Array for Plenoptic Imaging Sensors.

Microlens array (MLA) errors in plenoptic cameras can cause the confusion or mismatching of 4D spatio-angular information in the image space, significantly affecting the accuracy and efficiency of target reconstruction. In this paper, we present a high-accuracy correction method for light fields distorted by MLA errors. Subpixel feature points are extracted from the microlens subimages of a raw image to obtain correction matrices and perform registration of the corresponding subimages at a subpixel level.

Generation of a multiplex mutagenesis population via pooled CRISPR-Cas9 in soya bean.

The output of genetic mutant screenings in soya bean [Glycine max (L.) Merr.] has been limited by its paleopolypoid genome.

Responsibility and Sustainability in Brain Science, Technology, and Neuroethics in China-a Culture-Oriented Perspective.

The China Brain Project is in development. Integrating an ethical framework to identify and assess ethical challenges and plan for solutions is a priority. Here Wang et al.

Prevalence and risk factors associated with hyperuricemia among working population at high altitudes: a cross-sectional study in Western China.

Chronic exposure to high altitude may lead to hyperuricemia. We investigated the prevalence of hyperuricemia and its risk factors among employees in high-altitude areas. A cross-sectional survey with cluster sampling was performed at 23 worksites on the Qinghai-Tibet Plateau.

The Disease Burden of Atrial Fibrillation in China from a National Cross-sectional Survey.

Atrial fibrillation (AF) is the most common type of arrhythmia, which is a significant public health issue. We aimed to determine the disease burden of AF in China. We used a recent national survey with stratified multistage random sampling from general Chinese population to estimate the AF disease burden, which enrolled 34,994 people aged 35 years or older all over China.

Rectification of Images Distorted by Microlens Array Errors in Plenoptic Cameras.

A plenoptic cameras is a sensor that records the 4D light-field distribution of target scenes. The surface errors of a microlens array (MLA) can cause the degradation and distortion of the raw image captured by a plenoptic camera, resulting in the confusion or loss of light-field information. To address this issue, we propose a method for the local rectification of distorted images using white light-field images.

4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol is a potential agent for gout therapy as a dual inhibitor of XOD and NLRP3.

Backgound: Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) in the joint. Both anti-hyperuricemia and anti-inflammation could be gout therapeutic strategies, whereas ideal drugs for gout treatment are deficient.

Purpose: 4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol (CBED) was obtained from a cluster of deoxybenzoins derivatives synthesized by our research group with potent anti-hyperuricemic and anti-inflammatory activities, which was expected to be a dual inhibitor of xanthine oxidase (XOD) and NOD-like receptor protein 3 (NLRP3).

The Multivariate Regression Statistics Strategy to Investigate Content-Effect Correlation of Multiple Components in Traditional Chinese Medicine Based on a Partial Least Squares Method.

Amultivariate regression statisticstrategy was developed to clarify multi-components content-effect correlation ofpanaxginseng saponins extract and predict the pharmacological effect by components content. In example 1, firstly, we compared pharmacological effects between saponins extract and individual saponin combinations. Secondly, we examined the anti-platelet aggregation effect in seven different saponin combinations of ginsenoside Rb1, Rg1, Rh, Rd, Ra3 and notoginsenoside R1.