Publications by authors named "Sunil Kumar Shambu"

Article Synopsis
  • This study investigates the prevalence of CYP2C19 alleles, focusing on loss-of-function (LoF) alleles (CYP2C19∗2, CYP2C19∗3) and gain-of-function (GoF) alleles (CYP2C19∗17) in a population of 300 healthy adults.
  • Researchers used allele-specific PCR to determine the frequencies of these alleles and the resulting metabolic phenotypes (ultra-rapid, extensive, intermediate, and poor metabolizers).
  • Results showed a high frequency of poor metabolizers (12.67%) and recommended pre-treatment genotype testing to tailor drug dosages and reduce adverse effects.
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COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-II) has become a global pandemic disrupting public health services. Telemedicine has emerged as an important tool to deliver care during these situations. Patients receiving Vitamin K antagonists (VKA) require structured monitoring which has posed a challenge during this pandemic.

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We aimed to assess the clinical pharmacist-initiated telephone-based patient education and self-management support for patients with cardiovascular disease during the nationwide lockdown during COVID-19 pandemic. A prospective single-center telephone-based cross-sectional study was conducted among patients at the Cardiology Department and its speciality clinic at a 1,800-bed tertiary care hospital in Southern India. A validated 8-item clinical pharmacist aided on-call questionnaire with two Domains was administered during and after lockdown (15 March and 8 June 2020).

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Epicardial fat thickness (EFT) reflects visceral adiposity and is associated with coronary artery disease (CAD). This study aimed to assess the correlation of echocardiographic EFT with the severity of CAD and to determine the EFT cut-off to predict CAD. EFT was measured in 503 patients undergoing coronary angiogram.

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