Transcatheter closure of a large aortopulmonary window using a Lifetech™ Konar-MF occluder device.

Aortopulmonary window is a rare CHD, which comprises a communication between the ascending aorta and the pulmonary artery. The standard treatment of aortopulmonary window is surgical; however, few cases are amenable to closure via percutaneous intervention. We present a case of aortopulmonary window closure using Lifetech™ Konar-MF occluder device (Lifetech Scientific Co.

Pattern of Medical Device Adverse Events in a Tertiary Care Hospital in Northern India: An Ambispective Study.

Background: Knowledge about the pattern of adverse events caused by medical devices (MDs) is limited in India. We aimed to assess the pattern of MD adverse events (MDAEs) in a tertiary hospital in Northern India.

Materials And Methods: This descriptive study was conducted ambispectively at various clinical departments of PGIMER, Chandigarh.

Development of AI-based hybrid soft computing models for prediction of critical river water quality indicators.

Prediction of river water quality indicators (RWQIs) using artificial intelligence (AI)-based hybrid soft computing modeling techniques could provide essential predictions required for efficient river health planning and management. The study described the development of a novel AI-based relative weighted ensemble (AIRWE) hybrid model for predicting critical RWQIs, i.e.

Hydrogen sulfide promotes migration of trophoblast cells by a Rho GTPase mediated actin cytoskeleton reorganization.

Introduction: Preeclampsia (PE) arises due to defective spiral artery remodelling which may be due to deficient migration of trophoblast cells. Migration of human endothelial cells has been shown to be promoted via Hydrogen sulphide(HS)/Rho GTPase Rac1 axis. This novel role of HS and its downstream processes have not yet been studied in the development and function of the placental trophoblast cells.

Green synthesis of novel biochar from Abelmoschus esculentus seeds for direct blue 86 dye removal: Characterization, RSM optimization, isotherms, kinetics, and fixed bed column studies.

The presence of Direct blue 86 dye (DB86) in water can lead to various health hazards to the humans and animals. The study explored efficacy of biochar derived from Abelmoschus Esculentus seeds (AESB) to remove DB86 from an aqueous solution. BET analysis of AESB delineated H4 classification with the predominance of micropores and mesopores spread throughout the surface.

Assessment of WHO core drug use indicators at a tertiary care Institute of National importance in India.

Rational prescribing of medicines is an important aspect of drug prescribing which helps in safe and efficacious and cost-effective drug treatment for patients. WHO Prescription indicators are intended to evaluate the services provided to the population concerning the rational use of medicines. The study aims to study prescription practices and rational use of medicines in the department of Internal medicine, using WHO prescribing indicators in a tertiary care teaching institute of national importance.

Central myelin-peripheral myelin junction in trigeminal, facial, and vestibulocochlear nerve: A histo-morphometric study.

Background: The study aimed to locate the central myelin and peripheral myelin junction (CNS PNS Junction, CPJ) in trigeminal, facial and vestibulocochlear nerves.

Methods: The cisternal segments of the nerves were cut from the brainstem to the proximal margin of trigeminal ganglia (trigeminal nerve) and internal acoustic meatus (facial and vestibulocochlear nerve) from cadavers. Horizontal sections of H&E stained slides were analysed and histo morphometry was performed.

Hydrochemical investigation of groundwater in a trans-Himalayan region of Ladakh, India, using geochemical modelling and entropy technique.

Evaluating the hydrogeochemistry and groundwater quality status is vital to understand the sources and extent of groundwater contamination. Chemometric analysis, geochemical modelling and entropy technique were explored to delineate the hydrogeochemistry of groundwater in the trans-Himalayan region. Analysis of hydrochemical facies revealed that 57.

Acalabrutinib as a novel hope for the treatment of breast and lung cancer: an in-silico proof of concept.

Drug repurposing is proved to be a groundbreaking concept in the field of cancer research, accelerating the pace of drug discovery by investigating the anti-cancer activity of the already approved drugs. On the other hand, it got highly benefitted from the advancement in the tools and techniques, which are used to build up the initial "proof of concept" based on the drug-target interaction. Acalabrutinib (ACL) is a well-known drug for the treatment of hematological malignancies.

Optimisation of process parameters of a thermal digester for the rapid conversion of food waste into value-added soil conditioner.

A novel thermal digester for converting food waste (FW) into nutrient-rich soil conditioner was designed and explored. The process variables, that is, temperature, the volume of the digestion chamber and the rotational speed of the digester were optimised using response surface methodology (RSM). The study revealed that the digester temperature of 150°C and rotational speed of 40 RPM required minimum time (180 minutes) for attaining the equilibrium moisture with a minimum energy consumption of 0.

Comparison of Midazolam and Propofol Infusion to Suppress Stress Response in Patients With Severe Traumatic Brain Injury: A Prospective, Randomized Controlled Trial.

Objective: The stress response following traumatic brain injury (TBI) is a preventable cause of secondary brain injury. This can be prevented using sedation in the intensive care unit (ICU). To date, the choice of sedative agent for preventing stress response is not well-studied in literature.

Application of Monte Carlo simulation for carcinogenic and non-carcinogenic risks assessment through multi-exposure pathways of heavy metals of river water and sediment, India.

Heavy metal contamination has severe detrimental impacts on the entire river ecosystem's quality and causes potential risks to human health. An integrated approach comprising deterministic and probabilistic (Monte Carlo simulation) models with sensitivity analysis was adopted to determine heavy metals' chronic daily intake (CDI) and their associated health risks from the riverine ecosystem. Both carcinogenic and non-carcinogenic risks of water and sediment were estimated through multi-exposure pathways.

Investigating the dynamics of ammonia volatilisation and the role of additives in thermal digestion of food waste.

Averting nutrient volatilisation in thermal treatment of organic waste is a challenging task. The dynamics of ammonia volatilisation and the role of additives in preventing the losses of nutrients in thermal digestion of food waste (FW) were explored. The experimental trials were performed in a convective dehydrator at different combinations of temperatures and airflow velocities.

Performance study of fly-ash-derived coagulant in removing natural organic matter from drinking water: synthesis, characterization, and modelling.

This study is an attempt to develop a liquid coagulant using fly ash (FAC) for removing natural organic matter (NOM) from drinking water systems. Acid-alkali leaching and polymerization technique was used for developing FAC. Characterization of FAC was performed using Fourier-transform infrared spectroscopy (FESEM), field emission scanning electron microscopy (FTIR), and X-ray diffraction (XRD) to assess the surface morphology and functional groups present.

Perspective on Cav-1 for its Potential as Newer Therapeutics for Parkinson's Disease.

Parkinson's disease (PD) is the second most common neurodegenerative disease affecting around 10 million people worldwide. Dopamine agonists that mimic the action of natural dopamine in the brain are the prominent drugs used in the management of PD symptoms. However, the therapy is limited to symptomatic relief with serious side effects.