Publications by authors named "Sunil B Kumaraswamy"
Colorectal cancer (CRC) is the third most common cancer; cancer biomarker discovery is important for disease detection and management. It is known that hyaluronic acid and its receptors are ubiquitously expressed in almost all human tissues. Earlier we have shown that a monoclonal antibody H11B2C2, presently known as UNIVmAb, reactive hyaladherin expressed in multiple human cancers mainly using immunohistochemistry.
View Article and Find Full Text PDFObjective: Management and diagnosis of multiple human cancers remains a challenge and search for a common biomarker is still debatable. In this manuscript we have evaluated the use of monoclonal antibody UNIVmAb, to detect the protein (H11) as a common biomarker for all cancers irrespective of the grade and origin. We have shown by both ELISA and Western Blot that the H11 protein, is a unique hyaluronan binding protein that has not been detected earlier.
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- Apolipoprotein M (apoM) is a protein found in HDL particles that potentially serves to reduce cardiovascular risk and maintain blood vessel integrity, especially in systemic lupus erythematosus (SLE) patients, who are at a higher risk for cardiovascular issues.
- A study measured apoM levels in 84 SLE patients and 79 healthy controls, finding that SLE patients had significantly lower apoM levels, which were inversely related to SLE disease activity (SLEDAI).
- The results suggest that lower apoM levels in SLE patients, particularly in younger individuals, may reflect increased disease activity and endothelial dysfunction, indicating a potential biomarker for monitoring these conditions.
Introduction: Apolipoprotein M (apoM) is present in 5% of high-density lipoprotein (HDL) particles in plasma. It is a carrier of sphingosine-1-phosphate (S1P), which is important for vascular barrier protection. The aim was to determine the plasma concentrations of apoM during sepsis and systemic inflammatory response syndrome (SIRS) and correlate them to levels of apolipoprotein A-I (apoA1), apolipoprotein B (apoB), HDL-, and low-density lipoprotein (LDL)-cholesterol.
View Article and Find Full Text PDFProtection of the endothelium is provided by circulating sphingosine-1-phosphate (S1P), which maintains vascular integrity. We show that HDL-associated S1P is bound specifically to both human and murine apolipoprotein M (apoM). Thus, isolated human ApoM(+) HDL contained S1P, whereas ApoM(-) HDL did not.
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