Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury.

Accidental high-dose radiation exposures can lead to multi-organ injuries, including radiation dermatitis. The types of cellular damage leading to radiation dermatitis are not completely understood. To identify the cellular mechanisms that underlie radiation-induced skin injury in vivo, we evaluated the time-course of cellular effects of radiation (14, 16 or 17 Gy X-rays; 0.

Protein Oxidation in the Lungs of C57BL/6J Mice Following X-Irradiation.

Damage to normal lung tissue is a limiting factor when ionizing radiation is used in clinical applications. In addition, radiation pneumonitis and fibrosis are a major cause of mortality following accidental radiation exposure in humans. Although clinical symptoms may not develop for months after radiation exposure, immediate events induced by radiation are believed to generate molecular and cellular cascades that proceed during a clinical latent period.

Driver-injury severity in single-vehicle crashes in California: A mixed logit analysis of heterogeneity due to age and gender.

This research develops a mixed logit model of driver-injury severity in single-vehicle crashes in California. The research especially considers the heterogeneous effects of age and gender. Older drivers (65+ years old) were found to have a random parameter with about half the population having a higher probability of a fatal injury given a crash than the comparison group of 25-64 year olds with all other factors than age kept constant.

Analyzing fault in pedestrian-motor vehicle crashes in North Carolina.

Crashes between pedestrians and motor vehicles are an important traffic safety concern. This paper explores the assignment of fault in such crashes, where observed factors are associated with pedestrian at fault, driver at fault, or both at fault. The analysis is based on police reported crash data for 1997 through 2000 in North Carolina, U.

Analysis of teenage seat belt use: from the 2007 Missouri high school seat belt survey.

Introduction: This study analyzed high school teenagers' seat belt use based on the observational surveys of more than 15,000 teenagers at 150 schools and was conducted in the state of Missouri, U.S., in 2007.

Age and pedestrian injury severity in motor-vehicle crashes: a heteroskedastic logit analysis.

This research explores the injury severity of pedestrians in motor-vehicle crashes. It is hypothesized that the variance of unobserved pedestrian characteristics increases with age. In response, a heteroskedastic generalized extreme value model is used.

Bicyclist injury severities in bicycle-motor vehicle accidents.

This research explores the factors contributing to the injury severity of bicyclists in bicycle-motor vehicle accidents using a multinomial logit model. The model predicts the probability of four injury severity outcomes: fatal, incapacitating, non-incapacitating, and possible or no injury. The analysis is based on police-reported accident data between 1997 and 2002 from North Carolina, USA.

Personal, temporal and spatial characteristics of seriously injured crash-involved seat belt non-users in Hawaii.

The characteristics of crash-involved seat belt non-users in a high use state (Hawaii) are examined in order to better design enforcement and education programs. Using police crash report data over a 10-year period (1986-1995), we compare belted and unbelted drivers and front seat occupants, who were seriously injured in crashes, in terms of personal (age, gender, alcohol involvement, etc.) and crash characteristics (time, location, roadway factors, etc.